P
Peter J. K. Kuppen
Researcher at Leiden University Medical Center
Publications - 302
Citations - 12565
Peter J. K. Kuppen is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 57, co-authored 288 publications receiving 11021 citations. Previous affiliations of Peter J. K. Kuppen include Free University of Brussels & Leiden University.
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Journal ArticleDOI
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery
Boudewijn E. Schaafsma,J. Sven D. Mieog,Merlijn Hutteman,Joost R. van der Vorst,Peter J. K. Kuppen,Clemens W.G.M. Löwik,John V. Frangioni,Cornelis J.H. van de Velde,Alexander L. Vahrmeijer +8 more
TL;DR: Although non‐targeted and non‐conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence‐guided surgery, understanding its advantages and limitations is of significant importance.
Journal ArticleDOI
Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer
Ramon Salazar,Paul Roepman,Gabriel Capellá,Victor Moreno,Iris Simon,Christa Dreezen,Adriana Lopez-Doriga,Cristina Santos,Corrie A.M. Marijnen,Johan Westerga,Sjoerd Bruin,David J. Kerr,Peter J. K. Kuppen,Cornelis J.H. van de Velde,Hans Morreau,Loes Van Velthuysen,Annuska M. Glas,Laura J. van't Veer,Rob A. E. M. Tollenaar +18 more
TL;DR: ColoPrint significantly improves the prognostic accuracy of pathologic factors and MSI in patients with stage II and III CRC and facilitates the identification of patients withStage II disease who may be safely managed without chemotherapy.
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HLA-E and HLA-G Expression in Classical HLA Class I-Negative Tumors Is of Prognostic Value for Clinical Outcome of Early Breast Cancer Patients
Esther M. de Kruijf,A. Sajet,Johanna G. H. van Nes,Russ Natanov,Hein Putter,Vincent T.H.B.M. Smit,Gerrit-Jan Liefers,Peter J. van den Elsen,Cornelis J.H. van de Velde,Peter J. K. Kuppen +9 more
TL;DR: Results provide further evidence that breast cancer is immunogenic, but also capable of evading tumor eradication by the host’s immune system, by up- or downregulation of HLA class Ia and class Ib loci.
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Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients
Esther M. de Kruijf,Johanna G. H. van Nes,Cornelis J.H. van de Velde,Hein Putter,Vincent T.H.B.M. Smit,Gerrit-Jan Liefers,Peter J. K. Kuppen,Rob A. E. M. Tollenaar,Wilma E. Mesker +8 more
TL;DR: Tumor–stroma ratio has proven to be an independent prognostic factor for RFP in breast cancer patients and especially in the triple-negative cancer subpopulation and could be easily implemented in routine daily pathology diagnostics.
Journal ArticleDOI
Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer
J. Sven D. Mieog,Susan Troyan,Merlijn Hutteman,Merlijn Hutteman,Kevin J. Donohoe,Joost R. van der Vorst,Alan Stockdale,Gerrit-Jan Liefers,Hak Soo Choi,Summer L. Gibbs-Strauss,Hein Putter,Sylvain Gioux,Peter J. K. Kuppen,Yoshitomo Ashitate,Clemens W.G.M. Löwik,Vincent T.H.B.M. Smit,Rafiou Oketokoun,Long Ngo,Cornelis J.H. van de Velde,John V. Frangioni,Alexander L. Vahrmeijer +20 more
TL;DR: The clinical translation of a new NIR fluorescence imaging system and the optimal ICG:HSA dose range for SLN mapping in breast cancer are described and defined.