The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery
Boudewijn E. Schaafsma,J. Sven D. Mieog,Merlijn Hutteman,Joost R. van der Vorst,Peter J. K. Kuppen,Clemens W.G.M. Löwik,John V. Frangioni,Cornelis J.H. van de Velde,Alexander L. Vahrmeijer +8 more
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TLDR
Although non‐targeted and non‐conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence‐guided surgery, understanding its advantages and limitations is of significant importance.Abstract:
Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.read more
Citations
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Journal ArticleDOI
Near-infrared fluorophores for biomedical imaging
TL;DR: This Review covers recent progress on near-infrared fluorescence imaging for preclinical animal studies and clinical diagnostics and interventions.
Journal ArticleDOI
Image-guided cancer surgery using near-infrared fluorescence.
Alexander L. Vahrmeijer,Merlijn Hutteman,Joost R. van der Vorst,Cornelis J. H. Van De Velde,John V. Frangioni +4 more
TL;DR: The concept of NIR fluorescence imaging for cancer surgery is introduced, the clinical trial literature to date is examined, and the key issues pertaining to imaging system and contrast agent optimization are outlined.
Journal ArticleDOI
A review of indocyanine green fluorescent imaging in surgery
Jarmo T. Alander,Ilkka Kaartinen,Aki Laakso,Tommi Pätilä,Thomas Spillmann,Valery V. Tuchin,Maarit Venermo,Petri Välisuo +7 more
TL;DR: An overview of the recent surgical intraoperational applications of indocyanine green fluorescence imaging methods, the basics of the technology, and instrumentation used is given.
Journal ArticleDOI
Structure-based programming of lymph-node targeting in molecular vaccines
Haipeng Liu,Kelly D. Moynihan,Yiran Zheng,Gregory L. Szeto,Adrienne V. Li,Bonnie Huang,Debra S. Van Egeren,Clara Park,Darrell J. Irvine +8 more
TL;DR: In this article, an albumin hitchhiking approach was applied to molecular vaccines, through the synthesis of amphiphiles (amph-vaccines) comprising an antigen or adjuvant cargo linked to a lipophilic albumin-binding tail by a solubility-promoting polar polymer chain.
Structure-based programming of lymph-node targeting in molecular vaccines
Haipeng Liu,Kelly D. Moynihan,Yiran Zheng,Gregory L. Szeto,Adrienne V. Li,Bonnie Huang,Debra S. Van Egeren,Clara Park,Darrell J. Irvine,Haipeng Lui +9 more
TL;DR: Administration of structurally optimized CpG-DNA/peptide amph-vaccines in mice resulted in marked increases in LN accumulation and decreased systemic dissemination relative to their parent compounds, leading to 30-fold increases in T-cell priming and enhanced anti-tumour efficacy while greatly reducing systemic toxicity.
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