Qianjin Liao

TL;DR: The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

TL;DR: It is concluded that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC.

TL;DR: Current knowledge regarding the functions ofcircRNAs in the hallmarks, stemness, resistance of cancer, as well as the possibility of circRNAs as biomarkers in cancer are summarized.

TL;DR: Current understanding of the NFκB-signaling pathway in cancer is updated and targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients.

TL;DR: The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of the immune response through both the release of metabolites and affecting the expression of immune molecules, such as lactate, PGE2, arginine, etc.