Role of the NFκB-signaling pathway in cancer
Longzheng Xia,Shiming Tan,Yujuan Zhou,Jingguan Lin,Heran Wang,Linda Oyang,Yutong Tian,Lu Liu,Min Su,Hui Wang,Deliang Cao,Qianjin Liao +11 more
TLDR
Current understanding of the NFκB-signaling pathway in cancer is updated and targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients.Abstract:
Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present, treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy, molecularly targeted therapy, gene therapy, and immunotherapy. However, the curative effects of these treatments have been limited thus far by specific characteristics of tumors. Abnormal activation of signaling pathways is involved in tumor pathogenesis and plays critical roles in growth, progression, and relapse of cancers. Targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients. NFκB is an important signaling pathway involved in pathogenesis and treatment of cancers. Excessive activation of the NFκB-signaling pathway has been documented in various tumor tissues, and studies on this signaling pathway for targeted cancer therapy have become a hot topic. In this review, we update current understanding of the NFκB-signaling pathway in cancer.read more
Citations
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Life, death, and autophagy in cancer: NF-κB turns up everywhere.
Daniela Verzella,Alessandra Pescatore,Daria Capece,Daria Capece,Davide Vecchiotti,Matilde Valeria Ursini,Guido Franzoso,Edoardo Alesse,Francesca Zazzeroni +8 more
TL;DR: How the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression is discussed.
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Honokiol: A Review of Its Anticancer Potential and Mechanisms.
TL;DR: Honokiol, a plant bioactive compound that originates mainly from the Magnolia species, is discussed, which possesses the capability to supress cell migration and invasion via the downregulation of several matrix-metalloproteinases and inhibiting cell migration, invasion, and metastasis.
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The Role of Macrophages in Cancer Development and Therapy.
TL;DR: In this paper, the role of TAMs in tumor development, including such aspects as protumorigenic inflammation, immune suppression, neoangiogenesis, and enhancement of tissue invasion and distant metastasis.
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Testicular cancer: Determinants of cisplatin sensitivity and novel therapeutic opportunities.
TL;DR: Pre-clinical successes with chemotherapy and targeted drug combinations fuel the need for further investigation in clinical setting, and patient-derived xenograft models hold potential for mechanistic studies and pre-clinical validation of novel therapeutic strategies in TC.
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Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras.
Kusal T. G. Samarasinghe,Saul Jaime-Figueroa,Michael Burgess,Dhanusha A. Nalawansha,Katherine Dai,Zhenyi Hu,Adrian Bebenek,Scott A. Holley,Craig M. Crews +8 more
TL;DR: In this article, a chimeric oligonucleotide that simultaneously binds to the transcription factor of interest (TOI) and to HaloTag-fused dCas9 protein was used to induce degradation of the former via the proteasomal pathway.
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TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
TL;DR: It is shown that micromolar concentrations of H2O2 can induce the expression and replication of HIV‐1 in a human T cell line and suggests that diverse agents thought to activate NF‐kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.