Yujuan Zhou

TL;DR: It is concluded that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC.

TL;DR: Current understanding of the NFκB-signaling pathway in cancer is updated and targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients.

TL;DR: The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of the immune response through both the release of metabolites and affecting the expression of immune molecules, such as lactate, PGE2, arginine, etc.

TL;DR: The utility of PD-L1 expression levels, mutation burden, immune cell infiltration, and immune cell function for predicting the efficacy ofPD-1/PD-L 1 blockade therapy is described and combination therapies proposed to provide a basis for improved precision medicine are proposed.

TL;DR: In this article, the stemness and differentiation potential of cancer stem cells are enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition (EET) and extracellular matrix (ECM) remodeling to form the specific mechanism of vasculogenic mimicry; they also summarized some of the current drugs targeting VM through these processes, suggesting a new reference for the clinical treatment of tumor angiogenesis.