R
Ran Li
Researcher at Harvard University
Publications - 29
Citations - 2243
Ran Li is an academic researcher from Harvard University. The author has contributed to research in topics: In vivo & Tumor microenvironment. The author has an hindex of 16, co-authored 27 publications receiving 1639 citations. Previous affiliations of Ran Li include Massachusetts Institute of Technology & University of Michigan.
Papers
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Journal ArticleDOI
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
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Microfluidic platforms for mechanobiology
TL;DR: In this paper, the authors discuss how microfluidics has transformed the study of mechanotransduction and discuss new biological insights that have been elucidated by using micro-fluidic experiments.
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Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model.
Nicholas J. Douville,Parsa Zamankhan,Yi-Chung Tung,Ran Li,Benjamin L. Vaughan,Cheng Feng Tai,Joshua B. White,Paul J. Christensen,Paul J. Christensen,James B. Grotberg,Shuichi Takayama,Shuichi Takayama +11 more
TL;DR: This research describes new tools for studying the combined effects of fluid mechanical and solid mechanical stress on alveolar cells and highlights the role that surface tension forces may play in the development of clinical pathology, especially under conditions of surfactant dysfunction.
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Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
TL;DR: Current assays are reviewed and the development of new microfluidic technologies for immunotherapy are discussed, showing their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring.
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Fabrication of two-layered channel system with embedded electrodes to measure resistance across epithelial and endothelial barriers.
Nicholas J. Douville,Yi-Chung Tung,Ran Li,Jack D. Wang,Mohamed E. H. ElSayed,Shuichi Takayama +5 more
TL;DR: A straightforward fabrication process for embedding Ag/AgCl electrodes within a two-layer poly(dimethylsiloxane) (PDMS) microfluidic chip where an upper and a lower channel are separated by a semiporous membrane allows for the reliable real-time measurement of transendothelial and transepithelial electrical resistance (TEER).