C
Christopher B. Rodell
Researcher at Drexel University
Publications - 54
Citations - 5040
Christopher B. Rodell is an academic researcher from Drexel University. The author has contributed to research in topics: Self-healing hydrogels & Medicine. The author has an hindex of 23, co-authored 47 publications receiving 3720 citations. Previous affiliations of Christopher B. Rodell include University of Pennsylvania & Harvard University.
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Journal ArticleDOI
Direct 3D Printing of Shear‐Thinning Hydrogels into Self‐Healing Hydrogels
TL;DR: Supramolecular hydrogels are used in the 3D printing of high-resolution, multi-material structures and support the patterning of multiple inks, cells, and void spaces.
Journal ArticleDOI
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
Journal ArticleDOI
3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking
Liliang Ouyang,Liliang Ouyang,Christopher B. Highley,Christopher B. Rodell,Wei Sun,Wei Sun,Jason A. Burdick +6 more
TL;DR: A dual-cross-linking hyaluronic acid system was studied here as a printable hydrogel ink, which encompassed both shear-thinning and self-healing behaviors via guest-host bonding, as well as covalent cross-l linking for stabilization using photopolymerization.
Journal ArticleDOI
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
Lin Guo,Hong Joo Kim,Hejia Wang,John Monaghan,Fernande Freyermuth,Julie C. Sung,Kevin J. O'Donovan,Charlotte M. Fare,Zamia Diaz,Nikita Singh,Zi Chao Zhang,Zi Chao Zhang,Maura Coughlin,Elizabeth A. Sweeny,Morgan E. DeSantis,Meredith E. Jackrel,Christopher B. Rodell,Jason A. Burdick,Oliver D. King,Aaron D. Gitler,Clotilde Lagier-Tourenne,Udai Bhan Pandey,Yuh Min Chook,J. Paul Taylor,J. Paul Taylor,James Shorter +25 more
TL;DR: Karyopherin-β2 prevents RBPs with PY-NLSs accumulating in stress granules, restores nuclear RBP localization and function, and rescues degeneration caused by disease-linked FUS and hnRNPA2, establishing that NIRs therapeutically restore RBP homeostasis and mitigate neurodegeneration.
Journal ArticleDOI
Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing
TL;DR: A class of hyaluronic acid (HA) hydrogels that form through noncovalent guest–host interactions, undergo disassembly when injected through a syringe and then reassemble within seconds (self-healing) when shear forces are removed is developed.