Rebecca Gingrich

TL;DR: Inhibition of a tyrosine kinase, be it c-kit, PDGFRβ or some other undefined target, may improve diabetes mellitus BG control and it deserves further study as a potential novel therapeutic option.

TL;DR: The observed heterogeneous patterns at baseline and during dose optimization of 5-FU levels suggest variations in 5-Fluorouracil metabolism among treated patients, which require further study of patient demographics, single nucleotide polymorphisms in Dihydropyrimidine Dehydrogenase (DPD), TS, or other genes that impact5-FU metabolism and gene expression changes in liver after 5-fu therapy.

TL;DR: Bvacizumab, a monoclonal antibody directed against the ligand, VEGF, has shown activity against RCC as a single agent in patients who had failed prior cytokine therapy and as first line therapy in combination with interferon.

TL;DR: It is hypothesize that the TMZ may be synergistic with HD IL-2 in a sequence-specific fashion by allowing the immune activation induced by the HDIL-2 to proceed without negative feedback applied by the T-reg population of cells whose major function is to inhibit an exuberant immune response.

TL;DR: The clinical experience suggests that soy supplementation using commercially available soy products can have durable beneficial effects on PSA levels and PSA kinetics in some men with prostate cancer.