R
Ruediger E. Port
Researcher at Genentech
Publications - 23
Citations - 4268
Ruediger E. Port is an academic researcher from Genentech. The author has contributed to research in topics: Population & Dynamic contrast-enhanced MRI. The author has an hindex of 17, co-authored 23 publications receiving 4047 citations. Previous affiliations of Ruediger E. Port include German Cancer Research Center.
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Journal ArticleDOI
Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols.
Paul S. Tofts,Gunnar Brix,David L. Buckley,Jeffrey L. Evelhoch,Elizabeth Henderson,Michael V. Knopp,Henrik Larsson,Ting-Yim Lee,Nina A. Mayr,Geoffrey J. M. Parker,Ruediger E. Port,June S. Taylor,Robert M. Weisskoff +12 more
TL;DR: A standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast‐enhanced T1‐weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd‐DTPA), are described.
Journal ArticleDOI
MR imaging of tumor microcirculation: Promise for the new millenium
June S. Taylor,June S. Taylor,Paul S. Tofts,Ruediger E. Port,Jeffrey L. Evelhoch,Michael V. Knopp,Wilburn E. Reddick,Wilburn E. Reddick,Val M. Runge,Nina A. Mayr +9 more
TL;DR: Clinical studies in this section show that some tumor types can be assessed by relatively simple dynamic measures and analyses, and suggest that a consensus on naming conventions (nomenclature) is needed to facilitate comparison and analysis of the results of studies conducted at different centers.
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Dynamic contrast-enhanced MRI using Gd-DTPA: interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors.
TL;DR: The shortest mean residence time in one of up to three tumor compartments, MRT*, was estimated using either the individual (reference) or a mean population arterial input function (AIF), which was unbiased but differed from the reference estimates 1.5‐fold or more in 23% of cases.
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Multicompartment analysis of gadolinium chelate kinetics: blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging.
TL;DR: It is concluded that individual CM kinetics in arterial blood should be taken into account when CM exchange rates between blood and tumor are to be determined and that a kinetic model for potentially malignant tumors should allow for kinetic heterogeneity.
Journal ArticleDOI
Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments--I. Single agent regimen.
Suresh H. Moolgavkar,E. Georg Luebeck,Mathisca C. M. de Gunst,Ruediger E. Port,Michael Schwarz +4 more
TL;DR: The method, which has a natural interpretation within the framework of a two-mutation model for carcinogenesis, yields estimates of rates of initiation and of growth rates of enzyme-altered foci as functions of dose of the agent under consideration.