Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols.
Paul S. Tofts,Gunnar Brix,David L. Buckley,Jeffrey L. Evelhoch,Elizabeth Henderson,Michael V. Knopp,Henrik Larsson,Ting-Yim Lee,Nina A. Mayr,Geoffrey J. M. Parker,Ruediger E. Port,June S. Taylor,Robert M. Weisskoff +12 more
Reads0
Chats0
TLDR
A standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast‐enhanced T1‐weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd‐DTPA), are described.Abstract:
We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast-enhanced T(1)-weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd-DTPA). These include a) the volume transfer constant K(trans) (min(-1)); b) the volume of extravascular extracellular space (EES) per unit volume of tissue v(e) (0 < v(e) < 1); and c) the flux rate constant between EES and plasma k(ep) (min(-1)). The rate constant is the ratio of the transfer constant to the EES (k(ep) = K(trans)/v(e)). Under flow-limited conditions K(trans) equals the blood plasma flow per unit volume of tissue; under permeability-limited conditions K(trans) equals the permeability surface area product per unit volume of tissue. We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards.read more
Citations
More filters
Journal ArticleDOI
AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients
Tracy T. Batchelor,A. Gregory Sorensen,A. Gregory Sorensen,Emmanuelle di Tomaso,Wei Ting Zhang,Wei Ting Zhang,Dan G. Duda,Kenneth S. Cohen,Kevin R. Kozak,Daniel P. Cahill,Poe Jou Chen,Poe Jou Chen,Mingwang Zhu,Mingwang Zhu,Marek Ancukiewicz,Maciej M. Mrugala,Scott R. Plotkin,Jan Drappatz,David N. Louis,Percy Ivy,David T. Scadden,Thomas Benner,Jay S. Loeffler,Patrick Y. Wen,Rakesh K. Jain +24 more
TL;DR: This study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor.
Journal ArticleDOI
Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy
Ravi Assomull,Sanjay K Prasad,Jonathan Lyne,Gillian Smith,E. Burman,Mohammed Khan,Mary N. Sheppard,Philip A. Poole-Wilson,Dudley J. Pennell +8 more
TL;DR: In DCM, midwall fibrosis determined by CMR is a predictor of the combined end point of all-cause mortality and cardiovascular hospitalization, which is independent of ventricular remodeling, which suggests a potential role for CMR in the risk stratification of patients with DCM.
Journal ArticleDOI
BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
Frank Hilberg,Gerald Juergen Roth,Martin Krššák,Susanna Kautschitsch,Wolfgang Sommergruber,Ulrike Tontsch-Grunt,Pilar Garin-Chesa,Gerd Bader,Andreas Zoephel,Jens Quant,Armin Heckel,Wolfgang Rettig +11 more
TL;DR: Although BIBF 1120 is rapidly metabolized in vivo by methylester cleavage, resulting in a short mean residence time, once daily oral dosing is fully efficacious in xenograft models, preclinical findings suggest that long-term clinical outcomes may improve with blockade of additional proangiogenic receptor tyrosine kinases.
Journal ArticleDOI
Imaging biomarker roadmap for cancer studies.
James P B O'Connor,Eric O. Aboagye,Judith E. Adams,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Sally F. Barrington,Ambros J. Beer,Ronald Boellaard,Sarah E. Bohndiek,J. Michael Brady,Gina Brown,David L. Buckley,Thomas L. Chenevert,Laurence P. Clarke,Sandra Collette,Gary Cook,Nandita M. deSouza,John Dickson,Caroline Dive,Jeffrey L. Evelhoch,Corinne Faivre-Finn,Ferdia A. Gallagher,Fiona J. Gilbert,Robert J. Gillies,Vicky Goh,John R. Griffiths,Ashley M. Groves,Steve Halligan,Adrian L. Harris,David J. Hawkes,Otto S. Hoekstra,Erich P. Huang,Brian Hutton,Edward F. Jackson,Gordon C Jayson,Andrew J. I. Jones,Dow-Mu Koh,Denis Lacombe,Philippe Lambin,Nathalie Lassau,Martin O. Leach,Ting-Yim Lee,Edward Leen,Jason S. Lewis,Yan Liu,Mark F. Lythgoe,Prakash Manoharan,Ross J. Maxwell,Kenneth A. Miles,Bruno Morgan,Steve Morris,Tony Ng,Anwar R. Padhani,Geoff J M Parker,Mike Partridge,Arvind P. Pathak,Arvind P. Pathak,Andrew C. Peet,Shonit Punwani,Andrew R. Reynolds,Simon P. Robinson,Lalitha K. Shankar,Ricky A. Sharma,Dmitry Soloviev,Sigrid Stroobants,Daniel C. Sullivan,Stuart A. Taylor,Paul S. Tofts,Gillian M. Tozer,Marcel van Herk,Simon Walker-Samuel,James Wason,Kaye J. Williams,Paul Workman,Thomas E. Yankeelov,Kevin M. Brindle,Lisa M. McShane,Alan Jackson,John C. Waterton +78 more
TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.
Journal ArticleDOI
The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy, and transfer to clinical practice.
TL;DR: The pathophysiologic basis of breast MR and the effects on acquisition technique and diagnostic accuracy, the diverging demands of high spatial and temporal resolution, and the different approaches that exist for image acquisition are reviewed.
References
More filters
Journal Article
The theory and applications of the exchange of inert gas at the lungs and tissues
Journal ArticleDOI
Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts.
Paul S. Tofts,Allan G. Kermode +1 more
TL;DR: Leakage of Gd‐DTPA through a defective blood‐brain barrier is measured quantitatively using dynamic MRI scanning, in which repeated scans are made after a bolus injection, and implies permeability in the range 4‐17 × 10−6 cm s−1, in broad agreement with other physiological methods.
Journal ArticleDOI
Modeling tracer kinetics in dynamic Gd-DTPA MR imaging
TL;DR: Three major models for collecting and analyzing dynamic MRI gadolinium‐diethylenetriamine penta‐acetic acid (Gd‐DTPA) data are examined and the ratio kep, the efflux rate constant, is the simplest to measure.
Journal ArticleDOI
The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method
TL;DR: It is shown that the permeability of a capillary area can be expressed by three parameters: the initial extraction of test substances added in a single injection to the blood flowing to an organ, the blood flow and the surface area of the capillaries.
Journal ArticleDOI
Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging.
TL;DR: A procedure for dynamic MR is presented, which accurately resolves the fast kinetics of tissue response during and after intravenous infusion of the paramagnetic contrast medium Gd-DTPA and yields a linear relationship between the measured MR signal and the Gd -DTPA concentration in the tissue.
Related Papers (5)
Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts.
Paul S. Tofts,Allan G. Kermode +1 more
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Martin O. Leach,Kevin M. Brindle,Jeffrey L. Evelhoch,John R. Griffiths,Michael R. Horsman,Alan Jackson,Gordon C Jayson,Ian Judson,Michael V. Knopp,R. J. Maxwell,D McIntyre,Anwar R. Padhani,Patricia M Price,R Rathbone,Gordon J. S. Rustin,Paul S. Tofts,Gillian M. Tozer,W Vennart,John C. Waterton,Stephen R. Williams,Paul Workman +20 more