S
Steven G. Gray
Researcher at Trinity College, Dublin
Publications - 163
Citations - 6137
Steven G. Gray is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 34, co-authored 162 publications receiving 5401 citations. Previous affiliations of Steven G. Gray include Dublin Institute of Technology & Harvard University.
Papers
More filters
Journal ArticleDOI
Tumour suppression by the human von Hippel-Lindau gene product.
TL;DR: It is determined that the protein product of the VHL gene is an approximately 30 kilodalton cytoplasmic protein and that reintroduction of wild-type, but not mutant, VHL into these cells had no demonstrable effect on their growth in vitro but inhibited their ability to form tumours in nude mice.
Journal ArticleDOI
The human histone deacetylase family.
Steven G. Gray,Tomas J. Ekström +1 more
TL;DR: The results obtained suggest that the number of histone deacetylases within the human genome may be as high as 17 and are discussed in relation to their homology to the yeast hist one de acetylases.
Journal ArticleDOI
Circular RNAs: Biogenesis, Function and Role in Human Diseases.
John Greene,John Greene,Anne-Marie Baird,Lauren Brady,Marvin Lim,Steven G. Gray,Raymond S. McDermott,Stephen P. Finn +7 more
TL;DR: It has been proposed that circRNA regulate gene expression at the transcriptional or post-transcriptional level by interacting with miRNAs and that circRNAs may have a role in regulating miRNA function in cancer initiation and progression.
Journal ArticleDOI
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.
Sandra Camelo,Antonio Iglesias,Daehee Hwang,Brice Due,Hoon Ryu,Hoon Ryu,Karen L. Smith,Karen L. Smith,Steven G. Gray,Jaime Imitola,German Duran,Basel Assaf,Brett Langley,Samia J. Khoury,George Stephanopoulos,Umberto De Girolami,Rajiv R. Ratan,Robert J. Ferrante,Robert J. Ferrante,Fernando Dangond +19 more
TL;DR: It is demonstrated that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA) reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates disability in the relapsing phase of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).
Journal ArticleDOI
Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature.
Martin P. Barr,Steven G. Gray,Andreas Hoffmann,Ralf A. Hilger,Juergen Thomale,John D. O’Flaherty,Dean A. Fennell,Derek J. Richard,John J. O'Leary,Kenneth J. O'Byrne +9 more
TL;DR: Characterisation studies demonstrated a decreased proliferative capacity of lung tumour cells in response to cisplatin, increased resistance to cisPlatin-induced cell death, accumulation of resistant cells in the G0/G1 phase of the cell cycle and enhanced clonogenic survival ability.