L
Lauren Brady
Researcher at Trinity College, Dublin
Publications - 23
Citations - 786
Lauren Brady is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Prostate cancer & Medicine. The author has an hindex of 8, co-authored 19 publications receiving 460 citations. Previous affiliations of Lauren Brady include Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Circular RNAs: Biogenesis, Function and Role in Human Diseases.
John Greene,John Greene,Anne-Marie Baird,Lauren Brady,Marvin Lim,Steven G. Gray,Raymond S. McDermott,Stephen P. Finn +7 more
TL;DR: It has been proposed that circRNA regulate gene expression at the transcriptional or post-transcriptional level by interacting with miRNAs and that circRNAs may have a role in regulating miRNA function in cancer initiation and progression.
Journal ArticleDOI
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling.
Lauren Brady,Michelle Kriner,Ilsa Coleman,Colm Morrissey,Martine Roudier,Lawrence D. True,Roman Gulati,Stephen R. Plymate,Zoey Zhou,Brian Birditt,Rhonda Meredith,Gary K. Geiss,Margaret L. Hoang,Joseph M. Beechem,Peter S. Nelson,Peter S. Nelson +15 more
TL;DR: In this article, the authors used digital spatial profiling (DSP) technology to quantitate transcript and protein abundance in spatially-distinct regions of metastatic prostate cancer (mPCs).
Journal ArticleDOI
Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide.
John Greene,Anne-Marie Baird,Orla Casey,Lauren Brady,Gordon Blackshields,Marvin Lim,Marvin Lim,Odharnaith O'Brien,Steven G. Gray,Raymond S. McDermott,Raymond S. McDermott,Stephen P. Finn +11 more
TL;DR: This is one of the first studies to profile and demonstrate discrete circRNAs expression patterns in an enzalutamide resistant cell line model of prostate cancer, and suggests that hsa_circ_0004870, through RBM39, may play a critical role in the development of enzyme resistance in CRPC.
Journal ArticleDOI
Exercise interventions for patients with advanced cancer: A systematic review of recruitment, attrition, and exercise adherence rates.
TL;DR: Broadening the eligibility criteria for exercise interventions may improve accrual numbers of patients with advanced cancer to exercise trials and ensure patients recruited are representative of clinical practice.
Journal ArticleDOI
N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance
Alain Chion,Jamie M. O’Sullivan,Clive Drakeford,Gudmundur Bergsson,Niall Dalton,Sonia Aguila,Soracha E. Ward,Padraic G. Fallon,Teresa M. Brophy,Roger J. S. Preston,Roger J. S. Preston,Lauren Brady,Orla Sheils,Michael Laffan,Thomas A. J. McKinnon,James S. O’Donnell +15 more
TL;DR: Novel findings support the hypothesis that conformation of the VWF A domains plays a critical role in modulating macrophage-mediated clearance of VWF in vivo.