S
Stephen P. Finn
Researcher at Trinity College, Dublin
Publications - 208
Citations - 8372
Stephen P. Finn is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 44, co-authored 184 publications receiving 7002 citations. Previous affiliations of Stephen P. Finn include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein,Adam J. Bass,So Young Kim,Ian F. Dunn,Serena J. Silver,Isil Guney,Isil Guney,Ellen Freed,Azra H. Ligon,Natalie Vena,Shuji Ogino,Milan G. Chheda,Milan G. Chheda,Pablo Tamayo,Stephen P. Finn,Yashaswi Shrestha,Yashaswi Shrestha,Jesse S. Boehm,Supriya Rani Jain,Emeric Bojarski,Craig H. Mermel,Craig H. Mermel,Jordi Barretina,Jordi Barretina,Jennifer Ang Chan,José Baselga,Josep Tabernero,David E. Root,Charles S. Fuchs,Massimo Loda,Ramesh A. Shivdasani,Matthew Meyerson,William C. Hahn +32 more
TL;DR: It is shown that the suppression of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels ofCDK8 and β-catenin hyperactivity, suggesting that therapeutic interventions targeting CDK 8 may confer a clinical benefit in β-Catenin-driven malignancies.
Journal ArticleDOI
Circular RNAs: Biogenesis, Function and Role in Human Diseases.
John Greene,John Greene,Anne-Marie Baird,Lauren Brady,Marvin Lim,Steven G. Gray,Raymond S. McDermott,Stephen P. Finn +7 more
TL;DR: It has been proposed that circRNA regulate gene expression at the transcriptional or post-transcriptional level by interacting with miRNAs and that circRNAs may have a role in regulating miRNA function in cancer initiation and progression.
Journal ArticleDOI
Gleason Score and Lethal Prostate Cancer: Does 3 + 4 = 4 + 3?
Jennifer R. Stark,Sven Perner,Meir J. Stampfer,Jennifer A. Sinnott,Stephen P. Finn,Anna Eisenstein,Jing Ma,Michelangelo Fiorentino,Tobias Kurth,Massimo Loda,Edward Giovannucci,Mark A. Rubin,Lorelei A. Mucci +12 more
TL;DR: Ignoring the predominance of Gleason pattern 4 in GS 7 cancers may conceal important prognostic information, and a standardized review of GS can improve prediction of PCa survival.
Journal ArticleDOI
Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer
Toshiro Migita,Stacey Ruiz,Alessandro Fornari,Michelangelo Fiorentino,Carmen Priolo,Giorgia Zadra,Fumika Inazuka,Chiara Grisanzio,Emanuele Palescandolo,Eyoung Shin,Christopher Fiore,Wanling Xie,Andrew L. Kung,Phillip G. Febbo,Aravind Subramanian,Lorelei A. Mucci,Jing Ma,Sabina Signoretti,Meir J. Stampfer,William C. Hahn,Stephen P. Finn,Massimo Loda +21 more
TL;DR: FASN can act as a prostate cancer oncogene in the presence of AR and that FASN exerts its oncogenic effect by inhibiting the intrinsic pathway of apoptosis by using the least squares means procedure.
Journal ArticleDOI
Potential role of miR-9 and miR-223 in recurrent ovarian cancer.
Alexandros Laios,Sharon O'Toole,Richard Flavin,Cara Martin,Lynn Kelly,M Ring,Stephen P. Finn,Ciara Barrett,Massimo Loda,Noreen Gleeson,Tom D'Arcy,E McGuinness,Orla Sheils,Brian L. Sheppard,John J O' Leary +14 more
TL;DR: A miRNA model for the molecular pathogenesis of recurrent ovarian cancer is proposed and strong evidence that miR-9 acts as a putative tumour suppressor gene in recurrent ovariancancer is provided.