S
Susanne Grether-Beck
Researcher at University of Düsseldorf
Publications - 91
Citations - 4554
Susanne Grether-Beck is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Human skin & Ceramide. The author has an hindex of 35, co-authored 86 publications receiving 4222 citations. Previous affiliations of Susanne Grether-Beck include Leibniz Institute for Neurobiology.
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Journal ArticleDOI
Cellular responses to nanoparticles: Target structures and mechanisms
Klaus Unfried,Catrin Albrecht,Lars-Oliver Klotz,Anna von Mikecz,Susanne Grether-Beck,Roel P. F. Schins +5 more
TL;DR: An integrated research protocol is proposed to identify fundamental cellular responses to NP in order to complement current toxicological screening strategies with a mechanism-based approach.
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Singlet Oxygen Mediates the UVA-induced Generation of the Photoaging-associated Mitochondrial Common Deletion
Mark Berneburg,Susanne Grether-Beck,Viola Kürten,Thomas Ruzicka,Karlis Briviba,Helmut Sies,Jean Krutmann +6 more
TL;DR: Evidence is provided for the involvement of reactive oxygen species in the generation of aging-associated mtDNA lesions in human cells and indicate a previously unrecognized role of singlet oxygen in photoaging of human skin.
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Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin.
Helger Stege,Len Roza,Arie A. Vink,Markus Grewe,Thomas Ruzicka,Susanne Grether-Beck,Jean Krutmann +6 more
TL;DR: It is demonstrated that topical application of photolyase is effective in dimer reversal and thereby leads to immunoprotection.
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Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Akimichi Morita,Thomas Werfel,Helger Stege,Constanze Ahrens,Karin Karmann,Markus Grewe,Susanne Grether-Beck,Thomas Ruzicka,Alexander Kapp,Lars-Oliver Klotz,Helmut Sies,Jean Krutmann +11 more
TL;DR: It is demonstrated that singlet oxygen is a potent trigger for the induction of human T cell apoptosis andSinglet oxygen generation is identified as a fundamental mechanism of action operative in phototherapy.
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Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis.
TL;DR: The data suggest that CD95L-induced apoptosis involves a sphingomyelinase- and PKCζ-dependent activation of NADPH oxidase isoforms, which is required for Yes/EGFR/CD95 interactions as upstream events of CD95 activation.