Journal ArticleDOI
Cellular responses to nanoparticles: Target structures and mechanisms
Klaus Unfried,Catrin Albrecht,Lars-Oliver Klotz,Anna von Mikecz,Susanne Grether-Beck,Roel P. F. Schins +5 more
TLDR
An integrated research protocol is proposed to identify fundamental cellular responses to NP in order to complement current toxicological screening strategies with a mechanism-based approach.Abstract:
Nanotechnology makes use of the special surface properties of extremely small particles. In this rapidly growing field, many different materials are produced for a multitude of diverse applications. Possible adverse health effects of these materials however are so far scarcely investigated and are therefore a special task of toxicology. Although strategies for risk assessment have been suggested, the authors of the current review emphasize the fact that on the cellular, subcellular and molecular levels, interactions between nanoparticles (NP) and target cells relevant for the induction of possible adverse health effects are poorly understood. On the basis of existing literature, the potentially most relevant cellular target sites of NP as well as the so far known major molecular events specifically induced by these xenobiotics are reviewed. Starting with NP uptake across the cell membrane, mechanisms of generation of reactive oxygen species and the activation of redox-sensitive signalling cascades are des...read more
Citations
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Journal ArticleDOI
Cytotoxicity of Nanoparticles
TL;DR: For nanoparticles to move into the clinical arena, it is important that nanotoxicology research uncovers and understands how these multiple factors influence the toxicity of nanoparticles so that their undesirable properties can be avoided.
Journal ArticleDOI
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
TL;DR: Recent results that address the toxicity of gold nanoparticles both in vitro and in vivo are discussed, and some experimental recommendations for future research at the interface of nanotechnology and biological systems are provided.
Journal ArticleDOI
Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity.
TL;DR: An overview of the current status of nanoemulsion formulation, fabrication, properties, applications, biological fate, and potential toxicity with emphasis on systems suitable for utilization within the food and beverage industry is provided.
Journal ArticleDOI
Toxicity of nanomaterials
Shahriar Sharifi,Shahed Behzadi,Sophie Laurent,M. Laird Forrest,Pieter Stroeve,Morteza Mahmoudi,Morteza Mahmoudi +6 more
TL;DR: A critical review of the biophysicochemical properties of various nanomaterials with emphasis on currently available toxicology data and methodologies for evaluating nanoparticle toxicity suggests that NPs may need to be sequestered into products so that the NPs are not released into the atmosphere during the product's life or during recycling.
Journal ArticleDOI
Magnetic nanoparticles for theragnostics.
TL;DR: The role of MNP size, composition and surface chemistry in their intracellular uptake, biodistribution, macrophage recognition and cytotoxicity, and review current studies on MNP toxicity, caveats of nanotoxicity assessments and engineering strategies to optimize MNPs for biomedical use are discussed.
References
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A Fujshima,T N Rao,D K Tryk +2 more
TL;DR: A review of the current progress in the area of TiO 2 photocatalysis, mainly photocatalytic air purification, sterilization and cancer therapy is discussed in this article.
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