R
Roel P. F. Schins
Researcher at University of Düsseldorf
Publications - 152
Citations - 12449
Roel P. F. Schins is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Oxidative stress & Inflammation. The author has an hindex of 56, co-authored 133 publications receiving 11415 citations. Previous affiliations of Roel P. F. Schins include University of Edinburgh & Maastricht University.
Papers
More filters
Journal ArticleDOI
The potential risks of nanomaterials: a review carried out for ECETOC
Paul J. A. Borm,David Robbins,Stephan Haubold,Thomas A. J. Kuhlbusch,Heinz Fissan,Ken Donaldson,Roel P. F. Schins,Vicki Stone,Wolfgang G. Kreyling,Jürgen Lademann,Jean Krutmann,David B. Warheit,Eva Oberdörster +12 more
TL;DR: This review shows that only few specific nanoparticles have been investigated in a limited number of test systems and extrapolation of this data to other materials is not possible, and limited ecotoxicological data for nanomaterials precludes a systematic assessment of the impact of Nanoparticles on ecosystems.
Journal ArticleDOI
Inhaled particles and lung cancer. Part A: Mechanisms.
TL;DR: Since most of the proposed molecular mechanisms underlying particle‐related carcinogenesis have been derived from in vitro studies, there is a need for future studies that evaluate the implication of these mechanisms for in vivo lung cancer development and transgenic and gene knockout animal models may provide a useful tool.
Journal ArticleDOI
Cellular responses to nanoparticles: Target structures and mechanisms
Klaus Unfried,Catrin Albrecht,Lars-Oliver Klotz,Anna von Mikecz,Susanne Grether-Beck,Roel P. F. Schins +5 more
TL;DR: An integrated research protocol is proposed to identify fundamental cellular responses to NP in order to complement current toxicological screening strategies with a mechanism-based approach.
Journal ArticleDOI
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).
Ken Donaldson,Vicki Stone,Paul J. A. Borm,Luis A Jimenez,Peter S. Gilmour,Roel P. F. Schins,Ad M. Knaapen,Irfan Rahman,Stephen P. Faux,David M. Brown,William MacNee +10 more
TL;DR: Oxidative stress arising from PM(10) has been shown to activate a number of redox-responsive signaling pathways in lung target cells that play a role in responses relevant to inflammation and pathological change, including MAPKs, NF-kappaB, AP-1, and histone acetylation.
Journal ArticleDOI
Development of in vitro systems for nanotoxicology : methodological considerations
TL;DR: Some of the most frequently used assays to assess the cytotoxity and biological reactivity of nanoparticles in vitro, ranging from simple cytotoxicity assays, to measurement of reactive oxygen species and oxidative stress, activation of proinflammatory signaling, and finally genotoxicity are outlined.