T
Thomas Cremer
Researcher at Ludwig Maximilian University of Munich
Publications - 290
Citations - 30574
Thomas Cremer is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chromatin & Chromosome. The author has an hindex of 88, co-authored 289 publications receiving 29486 citations. Previous affiliations of Thomas Cremer include Kaiserslautern University of Technology & Yale University.
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Journal ArticleDOI
Chromosome territories, nuclear architecture and gene regulation in mammalian cells.
TL;DR: The emerging view is that chromosomes are compartmentalized into discrete territories and the location of a gene within a chromosome territory seems to influence its access to the machinery responsible for specific nuclear functions, such as transcription and splicing.
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Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries
TL;DR: A method of in situ hybridization for visualizing individual human chromosomes from pter to qter, both in metaphase spreads and interphase nuclei, is reported and should be useful for both karyotypic studies and for the analysis of chromosome topography in interphase cells.
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Matrix‐based comparative genomic hybridization: Biochips to screen for genomic imbalances
Sabina Solinas-Toldo,Stefan Lampel,Stephan Stilgenbauer,Jeremy Nickolenko,Axel Benner,Hartmut Döhner,Thomas Cremer,Peter Lichter +7 more
TL;DR: A protocol that allows CGH to chips consisting of glass slides with immobilized target DNAs arrayed in small spots to be developed, providing a basis for the development of automated diagnostic procedures with biochips designed to meet clinical needs.
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Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes
Andreas Bolzer,Gregor Kreth,Irina Solovei,Daniela Koehler,Kaan Saracoglu,Christine Fauth,Stefan C. Müller,Roland Eils,Christoph Cremer,Michael R. Speicher,Thomas Cremer +10 more
TL;DR: Modeling of 3D CT arrangements suggests that cell-type-specific differences in radial CT arrangements are not solely due to geometrical constraints that result from nuclear shape differences, and gene-density-correlated arrangements of higher-order chromatin shared by all human cell types studied so far are found.
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Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
TL;DR: This work has shown that the dynamic nature of the positioning of genetic material in the nuclear space and the higher-order architecture of the nucleus are integrated is essential to the overall understanding of gene regulation.