Gregor Kreth

TL;DR: Modeling of 3D CT arrangements suggests that cell-type-specific differences in radial CT arrangements are not solely due to geometrical constraints that result from nuclear shape differences, and gene-density-correlated arrangements of higher-order chromatin shared by all human cell types studied so far are found.

TL;DR: It is concluded that nuclear functions in the studied cell types may not require reproducible side-by-side arrangements of specific homologous or non-homologous CTs, and that presently unknown factors may play a decisive role to enforce the different radial arrangements of large and small CTs observed in ellipsoid and spherical human cell nuclei.

TL;DR: In this paper, the interphase chromosome arrangement in Arabidopsis thaliana has been analyzed and compared to Drosophila, showing that only the nucleolus organizing region (NOR)-bearing chromosome 2 and 4 homologs associate more often than randomly.

TL;DR: Arrangements of chromosome territories in nuclei of chicken fibroblasts and neurons were analysed employing multicolour chromosome painting, laser confocal scanning microscopy and three-dimensional reconstruction to support the evolutionary conservation of several features of higher-order chromatin organization between mammals and birds.

TL;DR: The 3D structure of a well-annotated, highly conserved 4.3-Mb region on mouse chromosome 14 that contains four clusters of genes separated by gene “deserts” is investigated, suggesting dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization.