Thomas Skøt Jensen

TL;DR: High-resolution mass spectrometry–based proteomics was applied to investigate the proteome and phosphoproteome of the human cell cycle on a global scale and quantified 6027 proteins and 20,443 unique phosphorylation sites and their dynamics, finding that nuclear proteins and proteins involved in regulating metabolic processes have high phosphorylated site occupancy in mitosis, suggesting that these proteins may be inactivated by phosphorylate in mitotic cells.

TL;DR: It is illustrated that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism and better functional biological relevance than comparable resources.

TL;DR: The method represents a conceptual scaffold for organism-spanning analyses and reveals an extensive list of tissue-specific draft molecular pathways, both known and unexpected, that might be disrupted in disease.

TL;DR: A simple permutation-based method is presented that performs better than most existing methods and specifically affects methods that only model the shape of the expression profile without taking into account the magnitude of regulation.

TL;DR: This work shows that despite the fact the protein complexes involved in this process are largely the same among all eukaryotes, their regulation has evolved considerably, involving both transcriptional and post-translational layers that jointly control the dynamics of biological systems.