Babol University of Medical Sciences

About: Babol University of Medical Sciences is a education organization based out in Babol, Iran. It is known for research contribution in the topics: Population & Medicine. The organization has 3195 authors who have published 4005 publications receiving 39888 citations.

Biogenic and eco-benign synthesis of silver nanoparticles using jujube core extract and its performance in catalytic and pharmaceutical applications: Removal of industrial contaminants and in-vitro antibacterial and anticancer activities

Abstract: Biosynthesis of nanoparticles has been rapidly developed in various fields, due to their broad spectrum of applications in the fields of environmental, pharmacology, and medicine. In this study, facile, rapid, eco-friendly and cost-effective method was used to green synthesis of silver nanoparticles (AgNPs) using jujube core extract (AgNPs-JCE) and then used as antibacterial, anticancer and catalytic agents. The reaction parameters such as AgNO 3 concentration (1, 5, 10, 20 and 40 mM), reaction time (5, 30 and 60 min) and pH (without pH, 10 and 12) were discussed and optimized. The surface plasmon resonance peak at about 420 nm in the UV–Vis absorption spectrum confirmed the green synthesis of silver nanoparticles. Microscopic results revealed that the synthesized AgNPs-JCE were spherical in morphology with a size range of 25–35 nm.In addition, the subject AgNPs promising catalytic properties in the degradation of pollutants including rhodamine b (RhB) and eriochrome black T (EBT) as cationic and anionic contaminant under UV and visible light irradiations. The photocatalyst (AgNPs-JCE) exhibited the degradation of 90.9 % and 84.7% for RhB and EBT contaminants after 80 min under UV irradiation, respectively. The antibacterial activities of AgNPs-JCE was checked against E. coli as Gram-positive bacteria and K. pneumoniae and S. aureus as Gram-negative bacteria with MIC and MBC values of (1.26 and 1.26 μ g/ml), (2.5 and 2.5 μ g/ml), and (2.5 and 10 μ g/ml), respectively. Finally, the cytotoxicity of synthesized nanoparticles against AGS as human stomach cancer cell line was determined at several concentrations (2.5, 5, 10, 20, 50, and 100 μ g/ml) using MTT assay. Finding of this research suggested the suitability of AgNPs-JCE as pollutants degradation, antibacterial and anticancer drug development.

The role of fatty acids on ICSI outcomes: a prospective cohort study.

Abstract: Our objective was to determine the effect of fatty acids (FAs) in serum and follicular fluid (FF) on fertilization and intracytoplasmic sperm injection (ICSI) outcomes. One hundred five women aged 18–38 years undergoing ICSI were recruited in this prospective cohort study. oocyte and emberyo quality was morphologically assessed. FAs in serum and FF were analyzed, using gas chromatography–mass spectrometry (GC-MS). The mean number of mature oocytes was associated with serum levels of oleic acid (r = 0.58; P = 0.002). There were negative correlations between metaphase II oocytes and FF levels of stearic acid (r = −0.19; P = 0.04) and linolenic acid (r = −0.37; P = 0.004). According to the obtained Spearman’s correlation coefficients, serum levels of stearic, palmitoleic and tricosanoic acids were positively correlated with the percent of germinal vesicle (GV) stage oocyte. The mean serum level of eicosapentaenoic acid was significantly higher in pregnant women than in non-pregnant patients (P = 0.006). Good quality embryos’ percentages were negatively correlated with the concentrations of palmitic acid (r = −0.22; P = 0.02). After adjusting the effects of body mass index and age, total FAs were found to have a significant effect on the odds of having high-quality oocytes (percentage of oocytes > 80%; odds ratio =2.55; P = 0.054). Particular FAs affect oocyte maturation and implantation. Apparently, while higher FF levels of saturated FAs, especially palmitic and stearic acids, observed in some metabolic contexts have harmful effects on oocyte maturation and implantation, such effects can be counteracted and developmental competence can be enhanced (at least in vitro) by the presence of unsaturated FAs, e.g. oleic and eicosapentaenoic acids.

The effect of exercise on the prevention of gestational diabetes in obese and overweight pregnant women: a systematic review and meta-analysis

Abstract: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Contrary results have been found in some review articles that examine the effect of exercise activities on preventing GDM, regardless of obesity. Therefore, the aim of this study was to systematically review the articles on the effect of exercise activities on the prevention of GDM in obese and overweight pregnant women. Literature was retrieved by formally searching PubMed, Embase, Cochrane library, Web of Science, Scopus, Proquest and by hand searching of reference lists of related articles. Finally, a total of eight literatures included, and Review manager 5.3 and STATA 14.0 statistical software were utilized for processing. In order to investigate the effect of sports activities on the incidence of GDM, the risk ratio (RR), and for quantitative indices, the standardized mean difference (SMD) with 95% confidence interval (CI) for each study was calculated. Out of 5107 papers identified, eight papers with 1441 participants included in meta-analysis (intervention group 727, control group 714). In the intervention group, 143 (19.66%, 95% CI 76.83 to 22.74) and in the control group, 196 (27.45%, 95% CI 20.24 to 30.88%), pregnant women had diabetes. The RR of gestational diabetes was 0.76 (95% CI 0.56 to 1.03, I2 = 50%, P = 0.05). In studies that the time for the intervention was three times a week or less, effect of intervention was significant in reducing the incidence of diabetes (RR: 0.59, 95% CI 0.46 to 0.76, I2 = 0%, P = 0.47). However, in studies with repeat of intervention was more than three times a week, the effect of intervention between two intervention and control groups was not different (RR: 1.03, 95% CI 0.78 to 1.35, I2 = 0%, P = 0.46). The exercise activities, alone, in obese or overweight pregnant women did not have a significant effect on the overall incidence of GDM, but considering the effect measure, the incidence of GDM was 24% lower in the intervention group than control group. This difference is considerable in the two groups. As the systematic review literatures both represent the information gap on the research subject and pave the way for further studies so it seems that there is a need for more randomized controlled trials so that we can make a complete conclusion on the type, intensity and duration of exercise in preventing GDM.