Institution
Gulf Coast Regional Blood Center
About: Gulf Coast Regional Blood Center is a based out in . It is known for research contribution in the topics: Population & Allele. The organization has 6297 authors who have published 6917 publications receiving 198369 citations.
Topics: Population, Allele, Human leukocyte antigen, Antigen, Antibody
Papers published on a yearly basis
Papers
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TL;DR: It is hypothesize that, despite reported beneficial effects, storage in AS‐3 results in metabolic impairment weeks before the end of the unit shelf life.
112 citations
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TL;DR: Results indicate that α-dystroglycan is a dual receptor for agrin and laminin-2 in the Schwann cell membrane.
112 citations
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Nanjing Medical University1, Huazhong University of Science and Technology2, Sun Yat-sen University3, Peking Union Medical College4, Shanghai Jiao Tong University5, Zhejiang University6, Hubei University7, China Medical University (PRC)8, Xi'an Jiaotong University9, Central South University10, Gulf Coast Regional Blood Center11, Fudan University12, Guangxi University13, Peking Union Medical College Hospital14
TL;DR: A genome-wide association study in the Han Chinese population finds strong evidence of associations between cervical cancer and two new loci and provides new insights into the genetic etiology of cervical cancer.
Abstract: Ding Ma, Xing Xie, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.
111 citations
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TL;DR: It is reported here thatABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a−) blood type have inherited two null alleles of ABCG2.
Abstract: The breast cancer resistance protein, also known as ABCG2, is one of the most highly studied ATP-binding cassette (ABC) transporters because of its ability to confer multidrug resistance. The lack of information on the physiological role of ABCG2 in humans severely limits cancer chemotherapeutic approaches targeting this transporter. We report here that ABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a-) blood type have inherited two null alleles of ABCG2. We identified five frameshift and three nonsense mutations in ABCG2. We also show that the prevalence of the Jr(a-) blood type in the Japanese and European Gypsy populations is related to the p.Gln126* and p.Arg236* protein alterations, respectively. The identification of ABCG2(-/-) (Jr(a-)) individuals who appear phenotypically normal is an essential step toward targeting ABCG2 in cancer and also in understanding the physiological and pharmacological roles of this promiscuous transporter in humans.
111 citations
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TL;DR: Observations suggest that the presence of Gly-86 in the HLAβ-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.
Abstract: HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%; P < 0.0001). In the analysis of clinical parameters, 82.8% of patients bearing DRB1*1502 were treated with corticosteroids. DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05). These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.
111 citations
Authors
Showing all 6297 results
Name | H-index | Papers | Citations |
---|---|---|---|
Martin G. Larson | 171 | 620 | 117708 |
Ernest E. Moore | 132 | 1247 | 73396 |
Jeffery D. Molkentin | 131 | 482 | 61594 |
Mary M. Horowitz | 127 | 557 | 56539 |
Olivier Hermine | 111 | 1026 | 43779 |
Zaverio M. Ruggeri | 104 | 391 | 36417 |
Steven M. Albelda | 103 | 398 | 41200 |
Hans D. Ochs | 102 | 419 | 39881 |
Sanford J. Shattil | 99 | 239 | 30840 |
Michael P. Busch | 96 | 758 | 43075 |
Jinlong Yang | 95 | 765 | 35981 |
Hiroaki Okamoto | 94 | 722 | 39057 |
Irwin D. Bernstein | 89 | 311 | 26624 |
Mark J. Ratain | 88 | 651 | 34779 |
Edgar G. Engleman | 87 | 346 | 28243 |