Journal ArticleDOI
A review of the volatiles from the healthy human body
B P J de Lacy Costello,Anton Amann,Anton Amann,Huda Al-Kateb,C. Flynn,Wojciech Filipiak,Wojciech Filipiak,T Khalid,D. Osborne,Norman M. Ratcliffe +9 more
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TLDR
A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported and it is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of V OCs from healthy individuals.Abstract:
A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urine (279), and faeces (381) in apparently healthy individuals. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been grouped into tables according to their chemical class or functionality to permit easy comparison. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces. Careful use of the database is needed. The numbers may not be a true reflection of the actual VOCs present from each bodily excretion. The lack of a compound could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from blood compared to a large number on VOCs in breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. collecting excretions on glass beads and then heating to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of VOCs from healthy individuals. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.read more
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Journal ArticleDOI
The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
Anton Amann,Anton Amann,Ben de Lacy Costello,Wolfram Miekisch,Jochen K. Schubert,Bogusław Buszewski,Joachim D. Pleil,Norman M. Ratcliffe,Terence H. Risby +8 more
TL;DR: In future studies, combined investigations of a particular compound with regard to human matrices such as breath, urine, saliva and cell culture investigations will lead to novel scientific progress in the field.
Journal ArticleDOI
Metabolomics for Investigating Physiological and Pathophysiological Processes
TL;DR: How metabolomics is yielding important new insights into a number of important biological and physiological processes is explored, with a major focus on illustrating how metabolomics and discoveries made through metabolomics are improving the understanding of both normal physiology and the pathophysiology of many diseases.
Journal ArticleDOI
A European respiratory society technical standard : exhaled biomarkers in lung disease
Ildiko Horvath,Peter J. Barnes,Stelios Loukides,Peter J. Sterk,Marieann Högman,Anna-Carin Olin,Anton Amann,Balazs Antus,Eugenio Baraldi,Andras Bikov,Agnes W. Boots,Lieuwe D. J. Bos,Paul Brinkman,C. Bucca,Giovanna Elisiana Carpagnano,Massimo Corradi,Simona M. Cristescu,Johan C. de Jongste,Anh Tuan Dinh-Xuan,Edward Dompeling,Niki Fens,Stephen J. Fowler,Jens M. Hohlfeld,Jens M. Hohlfeld,Olaf Holz,Quirijn Jöbsis,Kim D G van de Kant,Hugo H. Knobel,Konstantinos Kostikas,Lauri Lehtimäki,Jon O. Lundberg,Paolo Montuschi,Alain Van Muylem,Giorgio Pennazza,Petra Reinhold,Fabio Luigi Massimo Ricciardolo,Philippe P.R. Rosias,Marco Santonico,Marc P. van der Schee,Frederik-Jan van Schooten,Antonio Spanevello,Thomy Tonia,Teunis J. Vink +42 more
TL;DR: Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice, and highlighting future research priorities in the field.
Journal ArticleDOI
Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules
Morad Nakhleh,Haitham Amal,Raneen Jeries,Yoav Y. Broza,Manal Aboud,A'laa Gharra,Hodaya Ivgi,Salam Khatib,Shifaa' Badarneh,Lior Har-Shai,Lea Glass-Marmor,Izabella Lejbkowicz,Ariel Miller,Samih Badarny,Raz Winer,John P.M. Finberg,Sylvia Cohen-Kaminsky,Frédéric Perros,David Montani,Barbara Girerd,Gilles Garcia,Gérald Simonneau,Farid Nakhoul,Shira Baram,Raed Salim,Marwan Hakim,Maayan Gruber,Ohad Ronen,Tal Marshak,Ilana Doweck,Ofer Nativ,Zaher Bahouth,Da-you Shi,Wei Zhang,Qing-Ling Hua,Yue-Yin Pan,Li Tao,Hu Liu,Amir Karban,Eduard Koifman,Tova Rainis,Roberts Skapars,Armands Sivins,Guntis Ancans,Inta Liepniece-Karele,Ilze Kikuste,Ieva Lasina,Ivars Tolmanis,Douglas W. Johnson,Stuart Z. Millstone,Jennifer Fulton,John W. Wells,Larry H. Wilf,Marc Humbert,Marcis Leja,Nir Peled,Hossam Haick +56 more
TL;DR: An artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath could contribute to one of the most important criteria for successful health intervention in the modern era.
Journal ArticleDOI
Breath analysis by nanostructured metal oxides as chemo-resistive gas sensors
TL;DR: In this paper, a review of advances in these technologies in connection to breath analysis are critically reviewed, focusing on chemo-resistive gas sensors for their low cost and portability highlighting their potential and challenges for breath analysis as they start to be used in studies involving humans.
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