Antimicrobial photodynamic therapy: An overview
TLDR
Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug and could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteria.Abstract:
Inflammatory periodontal disease caused by dental plaque is characterized by the clinical signs of inflammation and loss of periodontal tissue support The mechanical removal of this biofilm and adjunctive use of antibacterial disinfectants and antibiotics have been the conventional methods of periodontal therapy But the removal of plaque and the reduction in the number of infectious organisms can be impaired in sites with difficult access The possibility of development of resistance to antibiotics by the target organism has led to the development of a new antimicrobial concept with fewer complications Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteriaread more
Citations
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Nanomedicine in the Management of Microbial Infection - Overview and Perspectives.
TL;DR: An overview on the current progress of nanomedicine in the management of microbial infection, including diagnosis, antimicrobial therapy, drug delivery, medical devices, and vaccines, as well as perspectives on the opportunities and challenges in antimicrobial nanomedicsine are provided.
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Nanotechnology for Cancer Therapy Based on Chemotherapy.
TL;DR: To achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment.
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Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers.
Dong Wang,Li-Juan Niu,Zeng-Ying Qiao,Dong-Bing Cheng,Jiefei Wang,Yong Zhong,Feng Bai,Hao Wang,Hongyou Fan,Hongyou Fan +9 more
TL;DR: The ease of the synthesis of self-assembled porphyrin nanoparticles and light-triggered release of highly reactive moieties represent a completely different photosensitizer system for APDT application.
Journal ArticleDOI
Drug Carrier for Photodynamic Cancer Therapy
TL;DR: Several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer are summarized.
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Sunlight-Triggered Nanoparticle Synergy: Teamwork of Reactive Oxygen Species and Nitric Oxide Released from Mesoporous Organosilica with Advanced Antibacterial Activity
Julia Gehring,Bastian Trepka,Nele Klinkenberg,Hannah Bronner,David Schleheck,Sebastian Polarz +5 more
TL;DR: A new, sunlight-mediated organosilica nanoparticle (NP) system based on silver-free antibacterial activity is introduced and the high antibacterial efficiency of dual-action nanoparticles was demonstrated using disinfection assays with the pathogenic bacterium Pseudomonas aeruginosa.
References
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Book
Photodynamic Therapy
TL;DR: A comprehensive review of mechanisms of subcellular and tumor localization of photosensitizing agents, as well as of molecular, cellular, and tumor responses associated with photodynamic therapy, are discussed.
Journal ArticleDOI
Photodynamic therapy: a new antimicrobial approach to infectious disease?
Michael R. Hamblin,Tayyaba Hasan +1 more
TL;DR: All the available evidence suggests that multi-antibiotic resistant strains are as easily killed by PDT as naive strains, and that bacteria will not readily develop resistance to PDT.
Journal ArticleDOI
Photodynamic antimicrobial chemotherapy (PACT).
TL;DR: Photodynamic antimicrobial chemotherapy (PACT), which predates the related cancer regimen, is proposed as a potential, low-cost approach to the treatment of locally occurring infection.
Journal ArticleDOI
Definition of type I and type II photosensitized oxidation.
TL;DR: This editorial briefly reviews the history and mechanism of photosensitized oxidations in order to provide the background for the definition of Type I and Type I1 photoensitized oxidation reactions.
Journal ArticleDOI
Photophysical and photobiological processes in the photodynamic therapy of tumours
TL;DR: The purpose of this review article is to summarize the up-to-date knowledge on the mechanisms responsible for the induction of tumour necrotic reactions.
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Photodynamic therapy: a new antimicrobial approach to infectious disease?
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