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Open AccessJournal ArticleDOI

Antimicrobial photodynamic therapy: An overview

TLDR
Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug and could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteria.
Abstract
Inflammatory periodontal disease caused by dental plaque is characterized by the clinical signs of inflammation and loss of periodontal tissue support The mechanical removal of this biofilm and adjunctive use of antibacterial disinfectants and antibiotics have been the conventional methods of periodontal therapy But the removal of plaque and the reduction in the number of infectious organisms can be impaired in sites with difficult access The possibility of development of resistance to antibiotics by the target organism has led to the development of a new antimicrobial concept with fewer complications Photodynamic therapy (PDT) involves the use of low power lasers with appropriate wavelength to kill micro organisms treated with a photosensitizer drug PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periopathogenic bacteria

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Nanomedicine in the Management of Microbial Infection - Overview and Perspectives.

TL;DR: An overview on the current progress of nanomedicine in the management of microbial infection, including diagnosis, antimicrobial therapy, drug delivery, medical devices, and vaccines, as well as perspectives on the opportunities and challenges in antimicrobial nanomedicsine are provided.
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Nanotechnology for Cancer Therapy Based on Chemotherapy.

TL;DR: To achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment.
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Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers.

TL;DR: The ease of the synthesis of self-assembled porphyrin nanoparticles and light-triggered release of highly reactive moieties represent a completely different photosensitizer system for APDT application.
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Drug Carrier for Photodynamic Cancer Therapy

TL;DR: Several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer are summarized.
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Sunlight-Triggered Nanoparticle Synergy: Teamwork of Reactive Oxygen Species and Nitric Oxide Released from Mesoporous Organosilica with Advanced Antibacterial Activity

TL;DR: A new, sunlight-mediated organosilica nanoparticle (NP) system based on silver-free antibacterial activity is introduced and the high antibacterial efficiency of dual-action nanoparticles was demonstrated using disinfection assays with the pathogenic bacterium Pseudomonas aeruginosa.
References
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Journal ArticleDOI

Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy.

TL;DR: In this paper, the authors used 5-aminolevulinic acid-induced protoporphyrin IX (POPIX) to detect premalignant/malignant lesions in the oral cavity.
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Clinical photodynamic therapy of head and neck cancers-A review of applications and outcomes.

TL;DR: The clinical literature on photosensitizers used clinically in head and neck PD/PDT, including Photofrin, Photosan and Foscan, are reviewed to assist in the integration of these important modalities into the mainstream ofHead and neck oncological therapy.
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Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study.

TL;DR: A 1-week course of systemic M+A every 4 months, as the only therapy, arrests the progression of adult periodontitis and significantly improves the clinical parameters of the disease.
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Photodynamic therapy--a strategic review.

TL;DR: This review elucidates the evolution and use of photo dynamic therapy and finds that photodynamic therapy (PDT) is advantageous to suppress anaerobic bacteria and could be an alternative to conventional periodontal therapeutic methods.
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Photodynamic therapy in dermatology. Shedding a different light on skin disease.

TL;DR: The use of photochemical reactions mediated through the interaction of light, photosensitizing drugs, and oxygen is a common practice in photodynamic therapy (PDT) as mentioned in this paper.
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