Cardiovascular Disease Risk Factors and Cognition in the Elderly.
Elizabeth C. Leritz,Regina E. McGlinchey,Regina E. McGlinchey,Regina E. McGlinchey,Ida L. Kellison,James L. Rudolph,James L. Rudolph,James L. Rudolph,William P. Milberg,William P. Milberg,William P. Milberg +10 more
TLDR
It is critically important to consider risk factors for CVD in the elderly, and routine cognitive screenings are recommended, particularly when CVD risk factors are involved.Abstract:
While it is relatively widely known that cardiovascular disease (CVD) can result in cognitive decline, it is becoming increasingly clearer that actual risk factors for CVD, such as high blood pressure, diabetes, and obesity are also associated with alterations to brain structure and cognition. The prevalence of CVD risk factors increase exponentially with age and are often overlooked as a source of cognitive changes that are otherwise thought to be part of the 'normal' aging process. Associated cognitive changes are observed even at levels of risk that would be considered subclinical by current diagnostic convention, and are often significant enough to interfere with daily functional abilities. More importantly, if not controlled, CVD risk can lead to further decline, including cerebrovacsular disease and dementia. Thus, it is critically important to consider these factors in the elderly and we recommend more routine cognitive screenings, particularly when CVD risk factors are involved.read more
Citations
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Glymphatic failure as a final common pathway to dementia.
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TL;DR: Walking has been shown to improve set-shifting and inhibition in sedentary older persons without cognitive impairment and this finding is clinically relevant because participation in a walking program may prevent or postpone a (further) decline in executive function in those who are sedentary.
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Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways.
Takayuki Inoue,Masashi Tanaka,Shinya Masuda,Ryuji Ohue-Kitano,Hajime Yamakage,Kazuya Muranaka,Hiromichi Wada,Toru Kusakabe,Akira Shimatsu,Koji Hasegawa,Noriko Satoh-Asahara +10 more
TL;DR: These ω-3 PUFAs may suppress neuroinflammation through SIRT1-mediated inhibition of the microglial NF-κB stress response and ensue pro-inflammatory cytokine release, which is implicated in NAMPT-related and -unrelated pathways.
References
More filters
Journal ArticleDOI
Mild cognitive impairment
Serge Gauthier,Barry Reisberg,Michael Zaudig,Ronald C. Petersen,Karen Ritchie,Karl Broich,Sylvie Belleville,Henry Brodaty,David A. Bennett,Howard Chertkow,Jeffrey L. Cummings,Mony J. de Leon,Howard Feldman,Mary Ganguli,Harald Hampel,Philip Scheltens,Mary C. Tierney,Peter J. Whitehouse,Bengt Winblad +18 more
TL;DR: Mild cognitive impairment can be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension.
Journal Article
The Modified Mini-Mental State (3MS) examination.
Evelyn L. Teng,Helena C. Chui +1 more
TL;DR: The Modified Mini-Mental State (3MS) incorporates four added test items, more graded scoring, and some other minor changes to sample a broader variety of cognitive functions, cover a wider range of difficulty levels, and enhance the reliability and the validity of the scores.
Journal ArticleDOI
The Mini-Mental State Examination
TL;DR: The Mini-Mental State Examination was designed as a clinical method for grading cognitive impairment and produces a score that can be used to follow the course of patients or as a case detection technique after cutoff scores are established.
Journal ArticleDOI
Differential aging of the brain: Patterns, cognitive correlates and modifiers
Naftali Raz,Karen M. Rodrigue +1 more
TL;DR: This review of the extant literature on age-related differences and changes in brain structure, including postmortem and noninvasive magnetic resonance imaging (MRI) studies, surveys the evidence from volumetry, diffusion-tensor imaging, and evaluations of white matter hyperintensities and speculate on several proposed mechanisms of differential brain aging.
Journal ArticleDOI
Cognitive decline and dementia in diabetes- : systematic overview of prospective observational studies
TL;DR: Compared to people without diabetes, people with diabetes have a greater rate of decline in cognitive function and a greater risk of cognitive decline and cognitive dysfunction should be added to the list of chronic complications of diabetes.
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