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Open AccessJournal ArticleDOI

Cardiovascular Disease Risk Factors and Cognition in the Elderly.

TLDR
It is critically important to consider risk factors for CVD in the elderly, and routine cognitive screenings are recommended, particularly when CVD risk factors are involved.
Abstract
While it is relatively widely known that cardiovascular disease (CVD) can result in cognitive decline, it is becoming increasingly clearer that actual risk factors for CVD, such as high blood pressure, diabetes, and obesity are also associated with alterations to brain structure and cognition. The prevalence of CVD risk factors increase exponentially with age and are often overlooked as a source of cognitive changes that are otherwise thought to be part of the 'normal' aging process. Associated cognitive changes are observed even at levels of risk that would be considered subclinical by current diagnostic convention, and are often significant enough to interfere with daily functional abilities. More importantly, if not controlled, CVD risk can lead to further decline, including cerebrovacsular disease and dementia. Thus, it is critically important to consider these factors in the elderly and we recommend more routine cognitive screenings, particularly when CVD risk factors are involved.

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Journal ArticleDOI

Glymphatic failure as a final common pathway to dementia.

TL;DR: The ties that bind sleep, aging, Glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.
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Aging and ischemic stroke.

TL;DR: The number of incident strokes in older adults is expected to rise, presenting major challenges for clinicians and policy makers in the foreseeable future, and 10 risk factors that collectively account for 88% of the risk of stroke in all adults are identified.
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Frailty as a predictor of cognitive disorders: A systematic review and meta-analysis

TL;DR: It is confirmed that frail older adults were at higher risk of incident cognitive disorders than non-frail elders andFrailty status seems to be most associated with therisk of incident dementia.
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Executive functions of sedentary elderly may benefit from walking: a systematic review and meta-analysis.

TL;DR: Walking has been shown to improve set-shifting and inhibition in sedentary older persons without cognitive impairment and this finding is clinically relevant because participation in a walking program may prevent or postpone a (further) decline in executive function in those who are sedentary.
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Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways.

TL;DR: These ω-3 PUFAs may suppress neuroinflammation through SIRT1-mediated inhibition of the microglial NF-κB stress response and ensue pro-inflammatory cytokine release, which is implicated in NAMPT-related and -unrelated pathways.
References
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Journal Article

The Modified Mini-Mental State (3MS) examination.

TL;DR: The Modified Mini-Mental State (3MS) incorporates four added test items, more graded scoring, and some other minor changes to sample a broader variety of cognitive functions, cover a wider range of difficulty levels, and enhance the reliability and the validity of the scores.
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The Mini-Mental State Examination

TL;DR: The Mini-Mental State Examination was designed as a clinical method for grading cognitive impairment and produces a score that can be used to follow the course of patients or as a case detection technique after cutoff scores are established.
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Differential aging of the brain: Patterns, cognitive correlates and modifiers

TL;DR: This review of the extant literature on age-related differences and changes in brain structure, including postmortem and noninvasive magnetic resonance imaging (MRI) studies, surveys the evidence from volumetry, diffusion-tensor imaging, and evaluations of white matter hyperintensities and speculate on several proposed mechanisms of differential brain aging.
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Cognitive decline and dementia in diabetes- : systematic overview of prospective observational studies

TL;DR: Compared to people without diabetes, people with diabetes have a greater rate of decline in cognitive function and a greater risk of cognitive decline and cognitive dysfunction should be added to the list of chronic complications of diabetes.
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