Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis
Morie A. Gertz,Raymond L. Comenzo,Rodney H. Falk,Jean Paul Fermand,Bouke P. C. Hazenberg,Philip N. Hawkins,Giampaolo Merlini,Philippe Moreau,Pierre Ronco,Vaishali Sanchorawala,Orhan Sezer,Alan Solomon,Giles Grateau +12 more
TLDR
A consensus panel was convened comprising 13 specialists actively involved in the treatment of patients with amyloidosis, and a consensus was developed defining each organ involved and the criteria for response.Abstract:
We undertook this study to develop uniformly accepted criteria for the definition of organ involvement and response for patients on treatment protocols for immunoglobulin light-chain amyloidosis (AL). A consensus panel was convened comprising 13 specialists actively involved in the treatment of patients with amyloidosis. Institutional criteria were submitted from each, and a consensus was developed defining each organ involved and the criteria for response. Specific criteria have been developed with agreed on definitions of organ and hematologic response as a result of discussions at the 10th International Symposium on Amyloid and Amyloidosis held in Tours, France, April 2004. These criteria now form the working definition of involvement and response for the purposes of future data collection and reporting. We report criteria that centers can now use to define organ involvement and uniform response criteria for reporting outcomes in patients with light-chain AL.read more
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Natural history and outcome in systemic AA amyloidosis.
Helen J. Lachmann,Hugh J. B. Goodman,Janet A. Gilbertson,J. Ruth Gallimore,Caroline A. Sabin,Julian D. Gillmore,Philip N. Hawkins +6 more
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Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens.
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TL;DR: The development of a highly specific and sensitive novel test for the typing of amyloidosis in routine clinical biopsy specimens that combines specific sampling by laser microdissection (LMD) and analytical power of tandem mass spectrometry (MS)-based proteomic analysis.
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New Criteria for Response to Treatment in Immunoglobulin Light Chain Amyloidosis Based on Free Light Chain Measurement and Cardiac Biomarkers: Impact on Survival Outcomes
Giovanni Palladini,Angela Dispenzieri,Morie A. Gertz,Shaji Kumar,Ashutosh D. Wechalekar,Philip N. Hawkins,Stefan Schönland,Ute Hegenbart,Raymond L. Comenzo,Efstathios Kastritis,Meletios A. Dimopoulos,Arnaud Jaccard,Catherine Klersy,Giampaolo Merlini +13 more
TL;DR: This study identifies and validates new criteria for response to first-line treatment in AL amyloidosis, based on their association with survival in large patient populations, and offers surrogate end points for clinical trials.
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International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders
Angela Dispenzieri,Robert A. Kyle,Giampaolo Merlini,Jesús F. San Miguel,Heinz Ludwig,Roman Hájek,Antonio Palumbo,Sundar Jagannath,J. Bladé,Sagar Lonial,Meletios A. Dimopoulos,Raymond L. Comenzo,H. Einsele,Bart Barlogie,KC Anderson,Morie A. Gertz,J L Harousseau,M. Attal,Patrizia Tosi,Pieter Sonneveld,Mario Boccadoro,Gareth J. Morgan,Paul G. Richardson,O. Sezer,Maria-Victoria Mateos,Michele Cavo,Douglas E. Joshua,Ingemar Turesson,Wenming Chen,K. Shimizu,R. L. Powles,S V Rajkumar,Brian G.M. Durie +32 more
TL;DR: Consensus guidelines for the use of the serum immunoglobulin-free light chain assay are provided, in the diagnosis and management of clonal PCD.
References
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