Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance
Andrew S. Flett,Jonathan Hasleton,Christopher Cook,Derek J. Hausenloy,Giovanni Quarta,Giovanni Quarta,Cono Ariti,Vivek Muthurangu,James C. Moon +8 more
TLDR
Regardless of the disease under study, the FWHM technique for LGE quantification gives LGE volume mean results similar to manual quantification and is statistically the most reproducible, reducing required sample sizes by up to one-half.Abstract:
Objectives The aim of this study was to compare the reproducibility of 7 late gadolinium enhancement (LGE) quantification techniques across 3 conditions in which LGE is known to be important: acute myocardial infarction (AMI), chronic myocardial infarction (CMI), and hypertrophic cardiomyopathy (HCM) Background LGE by cardiac magnetic resonance is the gold-standard technique for assessing myocardial scar No consensus exists on the best method for its quantification, and research in this area is scant Techniques include manual quantification, thresholding by 2, 3, 4, 5, or 6 SDs above remote myocardium, and the full width at half maximum (FWHM) technique To date, LGE has been linked to outcome in 3 conditions: AMI, CMI, and HCM Methods Sixty patients with 3 LGE etiologies (AMI, n = 20; CMI, n = 20; HCM, n = 20) were scanned for LGE LGE volume was quantified using the 7 techniques Mean LGE volume, interobserver and intraobserver reproducibility, and impact on sample size were assessed Results LGE volume varied significantly with the quantification method used There was no statistically significant difference between LGE volume by the FWHM, manual, and 6-SD or 5-SD techniques The 2-SD technique generated LGE volumes up to 2 times higher than the FWHM, 6-SD, and manual techniques The reproducibility of all techniques was worse in HCM than AMI or CMI The FWHM technique was the most reproducible in all 3 conditions compared with any other method (p Conclusions Regardless of the disease under study, the FWHM technique for LGE quantification gives LGE volume mean results similar to manual quantification and is statistically the most reproducible, reducing required sample sizes by up to one-halfread more
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Prevalence, distribution and clinical correlates of myocardial fibrosis in systemic lupus erythematosus: a cardiac magnetic resonance study.
Martin G. Seneviratne,Stuart M. Grieve,Gemma A. Figtree,Roger Garsia,David S. Celermajer,Stephen Adelstein,Rajesh Puranik +6 more
TL;DR: Mid-wall myocardial fibrosis occurs frequently in SLE and is strongly associated with advancing subject age, but not with SLE duration or severity, although this may be an epiphenomenon of age.
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Scar tissue–guided left ventricular lead placement for cardiac resynchronization therapy in patients with ischemic cardiomyopathy: An acute pressure-volume loop study
Gerben J. de Roest,LiNa Wu,Carel C. de Cock,Matthijs L. Hendriks,Peter Paul H.M. Delnoy,Albert C. van Rossum,Cornelis P. Allaart +6 more
TL;DR: In this article, the authors found that placing the LV lead over viable myocardium significantly improves pump function as compared with pacing at the location of scar tissue in patients with ischemic cardiomyopathy.
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Extra-cellular expansion in the normal, non-infarcted myocardium is associated with worsening of regional myocardial function after acute myocardial infarction.
Pankaj Garg,David A. Broadbent,David A. Broadbent,Peter P Swoboda,James R. J. Foley,Graham J. Fent,Tarique A Musa,David P Ripley,Bara Erhayiem,Laura E Dobson,Adam K McDiarmid,Philip Haaf,Ananth Kidambi,Saul Crandon,Pei G. Chew,R.J. van der Geest,John P Greenwood,Sven Plein +17 more
TL;DR: Investigating changes in the pattern of distribution of regional (normal, infarcted and oedematous segments) and global left ventricular (LV) ECV using semi-automated methods early and late after reperfused ST-elevation myocardial infarction found normal myocardium demonstrates subtle expansion of the extracellular volume at 3-month follow up.
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Multimodality Imaging Markers of Adverse Myocardial Remodeling in Aortic Stenosis
TL;DR: This review assesses how multimodality imaging evaluates AS myocardial hypertrophy and its components both before and after intervention, and seeks to highlight how care and outcomes in AS could be improved.
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Multimodality Imaging in Hypertrophic Cardiomyopathy for Risk Stratification
TL;DR: This review will focus on the application of imaging to assess established and emerging factors to be considered in sudden cardiac death risk stratification.
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