Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance
Andrew S. Flett,Jonathan Hasleton,Christopher Cook,Derek J. Hausenloy,Giovanni Quarta,Giovanni Quarta,Cono Ariti,Vivek Muthurangu,James C. Moon +8 more
TLDR
Regardless of the disease under study, the FWHM technique for LGE quantification gives LGE volume mean results similar to manual quantification and is statistically the most reproducible, reducing required sample sizes by up to one-half.Abstract:
Objectives The aim of this study was to compare the reproducibility of 7 late gadolinium enhancement (LGE) quantification techniques across 3 conditions in which LGE is known to be important: acute myocardial infarction (AMI), chronic myocardial infarction (CMI), and hypertrophic cardiomyopathy (HCM) Background LGE by cardiac magnetic resonance is the gold-standard technique for assessing myocardial scar No consensus exists on the best method for its quantification, and research in this area is scant Techniques include manual quantification, thresholding by 2, 3, 4, 5, or 6 SDs above remote myocardium, and the full width at half maximum (FWHM) technique To date, LGE has been linked to outcome in 3 conditions: AMI, CMI, and HCM Methods Sixty patients with 3 LGE etiologies (AMI, n = 20; CMI, n = 20; HCM, n = 20) were scanned for LGE LGE volume was quantified using the 7 techniques Mean LGE volume, interobserver and intraobserver reproducibility, and impact on sample size were assessed Results LGE volume varied significantly with the quantification method used There was no statistically significant difference between LGE volume by the FWHM, manual, and 6-SD or 5-SD techniques The 2-SD technique generated LGE volumes up to 2 times higher than the FWHM, 6-SD, and manual techniques The reproducibility of all techniques was worse in HCM than AMI or CMI The FWHM technique was the most reproducible in all 3 conditions compared with any other method (p Conclusions Regardless of the disease under study, the FWHM technique for LGE quantification gives LGE volume mean results similar to manual quantification and is statistically the most reproducible, reducing required sample sizes by up to one-halfread more
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Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.
Roberto Bolli,Atul R. Chugh,Domenico D'Amario,John H Loughran,Marcus F. Stoddard,Sohail Ikram,Garth M. Beache,Stephen G. Wagner,Annarosa Leri,Toru Hosoda,Fumihiro Sanada,Julius B Elmore,Polina Goichberg,Donato Cappetta,Naresh K Solankhi,Ibrahim Fahsah,D. Gregg Rokosh,Mark S. Slaughter,Jan Kajstura,Piero Anversa +19 more
TL;DR: It is suggested that intracoronary infusion of autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.
Journal ArticleDOI
Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing
Jeanette Schulz-Menger,David A. Bluemke,Jens Bremerich,Scott D. Flamm,Mark A. Fogel,Matthias G. Friedrich,Raymond J. Kim,Florian von Knobelsdorff-Brenkenhoff,Christopher M. Kramer,Dudley J. Pennell,Sven Plein,Eike Nagel +11 more
TL;DR: This document addresses the need for agreement on specific standards for the interpretation and post-processing of CMR studies by providing consensus recommendations developed by the Task Force for Post Processing of the Society for Cardiovascular MR.
Journal ArticleDOI
Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement
James C. Moon,Daniel Messroghli,Peter Kellman,Stefan K. Piechnik,Matthew D. Robson,Martin Ugander,Peter D. Gatehouse,Andrew E. Arai,Matthias G. Friedrich,Stefan Neubauer,Jeanette Schulz-Menger,Jeanette Schulz-Menger,Erik B. Schelbert +12 more
TL;DR: This document provides recommendations for clinical and research T1 and ECV measurement, based on published evidence when available and expert consensus when not, and addresses controversies in the field.
Journal ArticleDOI
Prognostic Value of Quantitative Contrast-Enhanced Cardiovascular Magnetic Resonance for the Evaluation of Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy
Raymond H. Chan,Barry J. Maron,Iacopo Olivotto,Michael J. Pencina,Gabriele Egidy Assenza,Tammy S. Haas,John R. Lesser,Christiane Gruner,Andrew M. Crean,Harry Rakowski,James E. Udelson,Ethan J. Rowin,Massimo Lombardi,Franco Cecchi,Benedetta Tomberli,Paolo Spirito,Francesco Formisano,Elena Biagini,Claudio Rapezzi,Carlo N. De Cecco,Camillo Autore,E. Francis Cook,Susie N. Hong,C. Michael Gibson,Warren J. Manning,Evan Appelbaum,Martin S. Maron +26 more
TL;DR: Extensive LGE measured by quantitative contrast enhanced CMR provides additional information for assessing SCD event risk among HCM patients, particularly patients otherwise judged to be at low risk.
Journal ArticleDOI
Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance
Atul R. Chugh,Garth M. Beache,John H Loughran,Nathan Mewton,Julius B Elmore,Jan Kajstura,Patroklos Pappas,Antone Tatooles,Marcus F. Stoddard,Joao A.C. Lima,Mark S. Slaughter,Piero Anversa,Roberto Bolli +12 more
TL;DR: Isolation of CSCs from cardiac tissue obtained in the operating room is feasible and does not alter practices during CABG surgery, and interim cardiac magnetic resonance results show that CSC infusion produces a striking improvement in both global and regional LV function, a reduction in infarct size, and an increase in viable tissue that persist at least 1 year and are consistent with cardiac regeneration.
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