Journal ArticleDOI
Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.
TLDR
This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.Abstract:
Chronic inflammation is being shown to be increasingly involved in the onset and development of several pathological disturbances such as arteriosclerosis, obesity, diabetes, neurodegenerative diseases and even cancer. Treatment for chronic inflammatory disorders has not been solved, and there is an urgent need to find new and safe anti-inflammatory compounds. Flavonoids belong to a group of natural substances occurring normally in the diet that exhibit a variety of beneficial effects on health. The anti-inflammatory properties of flavonoids have been studied recently, in order to establish and characterize their potential utility as therapeutic agents in the treatment of inflammatory diseases. Several mechanisms of action have been proposed to explain in vivo flavonoid anti-inflammatory actions, such as antioxidant activity, inhibition of eicosanoid generating enzymes or the modulation of the production of proinflammatory molecules. Recent studies have also shown that some flavonoids are modulators of proinflammatory gene expression, thus leading to the attenuation of the inflammatory response. However, much work remains to be done in order to achieve definitive conclusions about their potential usefulness. This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.read more
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Journal ArticleDOI
Phenolic compounds in Brassica vegetables.
TL;DR: The significance of phenolic compounds as a source of beneficial compounds for human health and the influence of environmental conditions and processing mechanisms on the phenolic composition of Brassica vegetables are reviewed.
Journal ArticleDOI
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
TL;DR: It is shown that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.
Journal ArticleDOI
Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action.
Ashraful Alam,Nusrat Subhan,Mahbubur Rahman,Shaikh Jamal Uddin,Hasan Mahmud Reza,Satyajit D. Sarker +5 more
TL;DR: The biologic activities of naringin and its aglycone naringenin are explored, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.
Journal ArticleDOI
Cinnamon: A Multifaceted Medicinal Plant
TL;DR: Cinnamon is one of the most important spices used daily by people all over the world and is reported to have activities against neurological disorders, such as Parkinson's and Alzheimer's diseases.
Journal ArticleDOI
Anti-inflammatory activity of natural dietary flavonoids
TL;DR: Current knowledge and underlying mechanisms on anti-inflammatory activities of flavonoids and their implicated effects in the development of various chronic inflammatory diseases are summarized.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal Article
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Inflammation and Atherosclerosis
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