Fundamentals of cancer metabolism
TLDR
A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.Abstract:
Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.read more
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Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma.
Jing Lin,Jing Lin,Jia Hui Jane Lee,Kathirvel Paramasivam,Elina Pathak,Zhenxun Wang,Zacharias A.D. Pramono,Bing Lim,Keng Boon Wee,Keng Boon Wee,Uttam Surana,Uttam Surana +11 more
TL;DR: In this article, splicing-modulating steric hindrance antisense oligonucleotides (shAONs) are used to induce exon skipping (half maximal inhibitory concentration [IC 50 ] at 3.5-7 nM), disrupt the open reading frame (ORF) of GLDC transcript (predising it for nonsense-mediated decay), halt cell proliferation, and prevent colony formation in both A549 cells and TIC-enriched NSCLC tumor sphere cells (TS32).
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Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
Kenji Ohshima,Satoshi Nojima,Shinichiro Tahara,Masako Kurashige,Keisuke Kawasaki,Yumiko Hori,Moyu Taniguchi,Yutaka Umakoshi,Daisuke Okuzaki,Naoki Wada,Naoki Wada,Jun-ichiro Ikeda,Eiichiro Fukusaki,Eiichi Morii +13 more
TL;DR: Serine racemase is shown to support colon-cancer growth, highlighting a new strategy that cancer cells use to maintain cellular pyruvate levels and mitochondrial mass and suggesting that SRR might be a molecular target for colorectal-cancer therapy.
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L-arginine/5-fluorouracil combination treatment approaches cells selectively: Rescuing endothelial cells while killing MDA-MB-468 breast cancer cells
Mozhgan Jahani,Mehri Azadbakht,Hassan Rasouli,Reza Yarani,Davood Rezazadeh,Nader Salari,Kamran Mansouri +6 more
TL;DR: Findings clearly suggest that L-arginine inhibits cell death induced by 5-FU in HUVECs through attenuating the adverse effects of5-FU, while it does not do so in breast cancer cells.
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Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo
Seth T. Gammon,Federica Pisaneschi,Madhavi Bandi,Melinda Smith,Yuting Sun,Yi Rao,Florian L. Muller,Franklin C. Wong,John de Groot,Jeffrey J. Ackroyd,Osama Mawlawi,Michael A. Davies,Y.N. Vashisht Gopal,M. Emilia Di Francesco,Joseph R. Marszalek,Mark W. Dewhirst,David Piwnica-Worms +16 more
TL;DR: 18F-fluoroazomycin arabinoside ([18F]FAZA), a 2-nitroimidazole-based hypoxia PET imaging agent, was combined with a rigorous test-retest imaging method for non-invasive quantification of the reversal of consumptive Hypoxia in vivo as a mechanism-specific pharmacodynamic (PD) biomarker of target engagement for IACS-010759.
Journal ArticleDOI
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance
TL;DR: In this paper, the role of NRF2 in cancer stem cells (CSCs), a small population of tumor cells responsible for therapy resistance and tumor relapse, is discussed.
References
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