Fundamentals of cancer metabolism
TLDR
A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.Abstract:
Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.read more
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Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation.
Katalin Erdelyi,Tamás Ditrói,Henrik J. Johansson,Ágnes Czikora,Noémi Balog,Laxmi Silwal-Pandit,Tomoaki Ida,Judit Olasz,Dorottya Hajdú,Zoltán Mátrai,Orsolya Csuka,Koji Uchida,József Tóvári,Olav Engebråten,Takaaki Akaike,Anne-Lise Børresen Dale,Miklós Kásler,Janne Lehtiö,Péter Nagy +18 more
TL;DR: In this paper, the authors showed that CBS silencing made BLBC cells less invasive, proliferate slower, more vulnerable to oxidative stress and cystine deprivation, prone to ferroptosis, and less responsive to HIF1α activation under hypoxia.
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Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells.
TL;DR: An in-depth review of how Vit.C plays an important role in targeting CSCs and its possible use as an adjuvant, neoadjuvant or co-treatment in the treatment of cancers is provided.
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TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment.
TL;DR: In this paper, the authors scrutinize TGF-β-mediated immune and stromal cell crosstalk within the tumor microenvironment (TME), with a primary focus on metabolic programs.
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Tumors sweeten macrophages with acids.
TL;DR: Acidic microenvironments induced by highly glycolytic tumor cells promote the noninflammatory polarization of tumor-associated macrophages, which leads to immunoevasion.
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Intersection of Epigenetic and Metabolic Regulation of Histone Modifications in Acute Myeloid Leukemia
TL;DR: This review will consider the role of two cellular processes, metabolism and epigenetics, in the development and progression of AML and highlight the studies that suggest an interconnection of therapeutic importance between the two.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.