Fundamentals of cancer metabolism
TLDR
A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.Abstract:
Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.read more
Citations
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Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy.
Devina Mitra,Devina Mitra,Silvia Vega-Rubin-de-Celis,Nadine Royla,Stephan Bernhardt,Stephan Bernhardt,Heike Wilhelm,Nooraldeen Tarade,Nooraldeen Tarade,Gernot Poschet,Michael Buettner,Ilona Binenbaum,Simone Borgoni,Simone Borgoni,Martina Vetter,Eva Johanna Kantelhardt,Christoph Thomssen,Aristotelis Chatziioannou,Rüdiger Hell,Stefan Kempa,Karin Müller-Decker,Stefan Wiemann,Stefan Wiemann +22 more
TL;DR: In this article, the authors show that glutamate pyruvate transaminase 2 (GPT2) is highly upregulated in aggressive breast cancers, particularly the triple-negative breast cancer subtype.
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Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive?
TL;DR: The role of lactate is discussed as a key molecule in carcinogenesis, acting as a fuel for cancer cell survival, growth, and proliferation, and potential therapeutic approaches to target lactate metabolism in cancer are described.
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Common biochemical properties of metabolic genes recurrently dysregulated in tumors
TL;DR: A computational model that integrates 142 metabolic features that can impact tumor fitness, including enzyme catalytic activity, pathway association, network topology, and reaction flux illuminates how enzyme activity and metabolic network architecture influences tumorigenesis.
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Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC).
Hung-Yu Lin,Pei-Yi Chu +1 more
TL;DR: In this paper, the role and mechanism of mitomiRs in triple negative breast cancer (TNBC) was reviewed and highlighted its clinical value in diagnosis and prognosis as well as vital advances on therapeutics of preclinical and clinical studies.
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Molecular profiling of microinvasive breast cancer microenvironment progression
Francesca Lessi,Cristian Scatena,Paolo Aretini,Michele Menicagli,Sara Franceschi,Antonio Giuseppe Naccarato,C.M. Mazzanti +6 more
TL;DR: It is observed that the stromal cells are necessary for the development and the maintenance of the tumor, especially in tumor progression, and the most important genes involved in the main metabolic pathways were analysed and the communications within the different cell compartments were highlighted.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.