Journal ArticleDOI
Nanocomposite materials with antimicrobial activity based on chitosan
TLDR
It is suggested that chitosan and its nanoparticles inhibits MMP-1 expression in skin fibroblasts and keratinocytes, and may thereby inhibit skin aging and facilitate the ECM remodelling phase of wound healing.Abstract:
Chitosan nanoparticles (CNP) were prepared by ionic gelation using sodium tripolyphosphate. Metal-enhanced CNP were prepared using the same procedure in the presence of Cu 2+ and Ag+, respectively. The nanoparticulate materials were characterised by FTIR, SEM and antimicrobial assays. The CNP showed higher antimicrobial effect than chitosan against S. saprophyticus and E. coli . The effect did not seem to depend on the molecular weight of the starting chitosan. Cu 2+ and Ag+, both known as antimicrobial agents, showed synergistic effects with chitosan against both organisms. The skin regenerative potential of CNP and metal-enhanced CNP was tested by assessing skin cell (fibroblast, keratinocyte) proliferation. The present study also suggests that chitosan and its nanoparticles inhibits MMP-1 expression in skin fibroblasts and keratinocytes, and may thereby inhibit skin aging and facilitate the ECM remodelling phase of wound healing.read more
Citations
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Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management.
TL;DR: This review briefed the recent development of different natural polymers and antibacterial nanoparticles to mitigate the diabetes mellitus based DFU.
Journal ArticleDOI
Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats.
TL;DR: It is concluded that chitosan-based copper nanocomposite efficiently enhanced cutaneous wound healing by modulation of various cells, cytokines and growth factors during different phases of healing process.
Journal ArticleDOI
Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review.
Syed Ahmed Shah,Muhammad Sohail,Shahzeb Khan,Muhammad Usman Minhas,Marcel de Matas,Victoria Sikstone,Zahid Hussain,Mudassir Abbasi,Mubeen Kousar +8 more
TL;DR: The pathophysiological conditions associated with chronic and diabetic wounds are reviewed, highlighting potential biomaterials and polymers for establishing drug delivery systems, specifically for the treatment of diabetic wounds and the promotion of the associated mechanisms involved in advanced wound healing.
Journal ArticleDOI
Effect of chitosan nanoparticles and pectin content on mechanical properties and water vapor permeability of banana puree films.
Milena dos Reis Martelli,Taís T. Barros,Márcia R. de Moura,Luiz H. C. Mattoso,Odilio B. G. Assis +4 more
TL;DR: The development of films from fruit purees head to a new strategy for plastic processing from natural resources, with small fractions of chitosan nanoparticles enhancing mechanical and thermal stability broadening potential film applications.
Journal ArticleDOI
Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms.
Oscar Castaño,Soledad Pérez-Amodio,Claudia Navarro-Requena,Miguel A. Mateos-Timoneda,Elisabeth Engel +4 more
TL;DR: The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signalling based on the biological mechanisms of the different events that occur in the host microenvironment to create instructive microenvironments for wound healing.
References
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Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
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