Journal ArticleDOI
Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience.
TLDR
Valproate is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies, and prescription of a broad-spectrum drug such as valproate has clear advantages in this situation.Abstract:
Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects involve a variety of mechanisms, including increased γ-aminobutyric acid (GABA)-ergic transmission, reduced release and/or effects of excitatory amino acids, blockade of voltage-gated sodium channels and modulation of dopaminergic and serotoninergic transmission.read more
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Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
Philip N. Patsalos,David J. Berry,Blaise F. D. Bourgeois,James C. Cloyd,Tracy A. Glauser,Svein I. Johannessen,Ilo E. Leppik,Torbjörn Tomson,Emilio Perucca +8 more
TL;DR: Evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context.
Journal ArticleDOI
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
TL;DR: The broad spectrum of antiepileptic efficacy of valproate is reflected in preclinical in vivo and in vitro models, including a variety of animal models of seizures or epilepsy as mentioned in this paper.
Journal ArticleDOI
Diverse mechanisms of antiepileptic drugs in the development pipeline
TL;DR: There is a remarkable array of new chemical entities in the current antiepileptic drug (AED) development pipeline, and some pipeline compounds are believed to act through conventional targets, whereas others are structurally novel and may act by novel mechanisms.
Journal ArticleDOI
Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review
Margarida F. B. Silva,C. C. P. Aires,Paula B.M. Luís,J. P. N. Ruiter,Lodewijk IJlst,Marinus Duran,Ronald J. A. Wanders,I. Tavares de Almeida +7 more
TL;DR: The cumulative consequences of VPA therapy in inborn errors of metabolism (IEMs) and the importance of recognizing an underlying IEM in cases of Vpa-induced steatosis and acute liver toxicity are two different concepts that will be emphasized.
Journal ArticleDOI
Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors
Alfonso Dueñas-González,Myrna Candelaria,Carlos Pérez-Plascencia,Enrique Pérez-Cárdenas,Erick de la Cruz-Hernandez,Luis A. Herrera +5 more
TL;DR: Existing preclinical and preliminary clinical data strongly suggest that VPA could be a drug that eventually will be used in combination therapies, either with classical cytotoxics, other molecular-targeted drugs or radiation in a number of solid tumors.
References
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