Journal ArticleDOI
Protein carbonyl groups as biomarkers of oxidative stress.
TLDR
The usage of protein CO groups as biomarkers of oxidative stress has some advantages in comparison with the measurement of other oxidation products because of the relative early formation and the relative stability of carbonylated proteins.About:
This article is published in Clinica Chimica Acta.The article was published on 2003-03-01. It has received 2097 citations till now. The article focuses on the topics: Protein Carbonylation & Protein oxidation.read more
Citations
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Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
TL;DR: The free radicals induced oxidative stress has been reported to be involved in several diseased conditions such as diabetes mellitus, neurodegenerative disorders, cardiovascular diseases, cardiovascular disease, respiratory diseases, cataract development, rheumatoid arthritis and in various cancers.
Journal ArticleDOI
Biomarkers of Oxidative Damage in Human Disease
TL;DR: Some of the more commonly used biomarkers of oxidative/nitrosative damage are discussed and selected examples of human studies are included.
Journal ArticleDOI
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging.
TL;DR: Spectroscopic Tagging helps clarify the role of X-ray diffraction in the determination of Higgs boson levels in the response of EMTs to injury.
Journal ArticleDOI
Protein oxidation and peroxidation.
TL;DR: In the presence of O2, high yields of peroxyl radicals and peroxides (protein peroxidation) are formed; the latter account for up to 70% of the initial oxidant flux as discussed by the authors.
Journal ArticleDOI
Role of oxidative stress in Alzheimer's disease (Review)
TL;DR: The current review examined the role of oxidative stress in AD, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants that can occur as a result of increased free radicals or a decrease in antioxidant defense.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity
Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Protein Oxidation in Aging, Disease, and Oxidative Stress
Book ChapterDOI
Carbonyl assays for determination of oxidatively modified proteins
TL;DR: New methods for determination ofcarbonyl content are presented, which are based on the reaction of carbonyl groups with 2,4-dinitrophenylhydrazine to form a 2, 4-d Initrophenolhydrazone, which provide substantial improvements in both sensitivity and specificity.