A
Adrian Brink
Researcher at University of Cape Town
Publications - 132
Citations - 6881
Adrian Brink is an academic researcher from University of Cape Town. The author has contributed to research in topics: Antimicrobial stewardship & Guideline. The author has an hindex of 33, co-authored 118 publications receiving 4668 citations. Previous affiliations of Adrian Brink include University of the Witwatersrand & Milpark Hospital.
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Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach.
Matteo Bassetti,Garyphallia Poulakou,Etienne Ruppé,Emilio Bouza,Sebastian Van Hal,Adrian Brink,Adrian Brink +6 more
TL;DR: The current standards of care and major recent advances with regard to antimicrobial resistance (AMR) are described and a prospective overview for the next 30 years in this field is given.
Journal ArticleDOI
Resistance to Colistin Associated with a Single Amino Acid Change in Protein PmrB among Klebsiella pneumoniae Isolates of Worldwide Origin
Aurélie Jayol,Laurent Poirel,Adrian Brink,Maria Virginia Villegas,Mesut Yilmaz,Patrice Nordmann +5 more
TL;DR: A key amino acid located in the PmrB protein is identified as being responsible for the overexpression of pmrCAB and pmrHFIJKLM operons, leading to resistance to colistin.
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A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail
Debra A. Goff,Ravina Kullar,Ellie J. C. Goldstein,Mark Gilchrist,Dilip Nathwani,Allen C. Cheng,Kelly A. Cairns,Kevin Escandón-Vargas,Maria Virginia Villegas,Adrian Brink,Dena van den Bergh,Marc Mendelson +11 more
TL;DR: It is recommended that antibiotic stewardship models need to evolve from infection specialist-based teams to develop and use cadres of health-care professionals, including pharmacists, nurses, and community health workers, to meet the needs of the global population.
Journal ArticleDOI
Antimicrobial stewardship across 47 South African hospitals: an implementation study
Adrian Brink,Angeliki P Messina,Charles Feldman,Guy A. Richards,Piet J. Becker,Debra A. Goff,Karri A. Bauer,Dilip Nathwani,Dena van den Bergh +8 more
TL;DR: The antimicrobial stewardship programme led to a reduction in mean antibiotic defined daily doses per 100 patient-days from 101·38 in the pre-implementation phase to 83·04 in the post-im implementation phase (p<0·0001), and health-care facilities with limited infectious diseases expertise can achieve substantial returns through pharmacist-led antimacterial stewardship programmes and by focusing on basic interventions.