Alessia Savoldi

TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.

TL;DR: Resistance of H pylori to antibiotics has reached alarming levels worldwide, which has a great effect on efficacy of treatment, and local surveillance networks are required to select appropriate eradication regimens for each region.

TL;DR: A theoretical framework in which consideration of the intervention rationale the intervention setting, intervention features and the intervention aims inform selection and prioritization of outcome measures is proposed, which will help researchers, funders and practitioners to most efficiently evaluate antimicrobial stewardship interventions.

TL;DR: Overall quality of antimicrobial stewardship studies is low and has not improved over time; most studies do not report clinical and microbiological outcome data; studies conducted in the community setting were associated with better quality.

TL;DR: In this paper, a systematic review and meta-analysis was performed including pharmacokinetic/pharmacodynamic (PK/PD) and time-kill (TK) studies examining the in vitro efficacy of antibiotic combinations against carbapenem-resistant Gram-negative bacilli (CR-GNB) infections.