A
Andrew Martens
Researcher at Washington University in St. Louis
Publications - 8
Citations - 498
Andrew Martens is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Leukemia & Haematopoiesis. The author has an hindex of 7, co-authored 8 publications receiving 394 citations.
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Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
James I. McDonald,Hamza Celik,Lisa E. Rois,Gregory Fishberger,Tolison Fowler,Ryan Rees,Ashley C. Kramer,Andrew Martens,John R. Edwards,Grant A. Challen +9 more
TL;DR: A CRISPR/dCas9-DNMT3A fusion protein to repress the expression of endogenous genes in combination with multiple guide RNAs can help to elucidate the role of DNA methylation in normal development and disease.
Journal ArticleDOI
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
Hamza Celik,Cates Mallaney,Alok Kothari,Elizabeth L. Ostrander,Elizabeth Eultgen,Andrew Martens,Christopher A. Miller,Jasreet Hundal,Jeffery M. Klco,Grant A. Challen +9 more
TL;DR: The data highlight crucial roles of Dnmt3a in normal and malignant hematopoiesis and suggest that a major role for this enzyme is to facilitate developmental progression of progenitor cells at multiple decision checkpoints.
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SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers
Matthew R. Hass,Hien-haw Liow,Xiaoting Chen,Xiaoting Chen,Ankur Sharma,Yukiko U. Inoue,Takayoshi Inoue,Ashley N. Reeb,Andrew Martens,Mary C. Fulbright,Saravanan Raju,Michael Stevens,Scott Boyle,Joo-Seop Park,Matthew T. Weirauch,Matthew T. Weirauch,Michael R. Brent,Raphael Kopan +17 more
TL;DR: Split DamID is developed, a protein complementation version of DamID, to mark genomic DNA bound in vivo by interacting or juxtapositioned transcription factors by enabling dynamic analysis of combinatorial protein-DNA transactions at a genome-wide level.
Journal ArticleDOI
Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Cates Mallaney,Elizabeth L. Ostrander,Hamza Celik,Ashley C. Kramer,Andrew Martens,Alok Kothari,Won Kyun Koh,Emily Haussler,Naoki Iwamori,Paul Gontarz,Bo Zhang,Grant A. Challen +11 more
TL;DR: A crucial role is identified for Kdm6b in regulating HSC self-renewal in different contexts, and the potential of KDM6B as a therapeutic target in different hematopoietic malignancies is highlighted.
Journal ArticleDOI
JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
Hamza Celik,Won Kyun Koh,Ashley C. Kramer,Elizabeth L. Ostrander,Cates Mallaney,Daniel A.C. Fisher,Jingyu Xiang,William C. Wilson,Andrew Martens,Alok Kothari,Gregory Fishberger,Eric Tycksen,Darja Karpova,Eric J. Duncavage,Youngsook Lee,Stephen T. Oh,Grant A. Challen +16 more
TL;DR: In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders and identifies potential therapeutic targets.