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Ashley C. Kramer
Researcher at Washington University in St. Louis
Publications - 21
Citations - 601
Ashley C. Kramer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Zebrafish & Haematopoiesis. The author has an hindex of 12, co-authored 19 publications receiving 443 citations. Previous affiliations of Ashley C. Kramer include Wayne State University & University of Minnesota.
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Journal ArticleDOI
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
James I. McDonald,Hamza Celik,Lisa E. Rois,Gregory Fishberger,Tolison Fowler,Ryan Rees,Ashley C. Kramer,Andrew Martens,John R. Edwards,Grant A. Challen +9 more
TL;DR: A CRISPR/dCas9-DNMT3A fusion protein to repress the expression of endogenous genes in combination with multiple guide RNAs can help to elucidate the role of DNA methylation in normal development and disease.
Journal ArticleDOI
Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness.
Elizabeth L. Ostrander,Ashley C. Kramer,Cates Mallaney,Hamza Celik,Won Kyun Koh,Jake Fairchild,Emily Haussler,Christine R. Zhang,Grant A. Challen +8 more
TL;DR: The effect of Tet2 mutation manifests more profound myeloid lineage skewing in committed hematopoietic progenitor cells rather than long-term HSCs, and molecular characterization revealed divergent transcriptomes and chromatin accessibility underlying these functional differences.
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Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression
Troy C. Lund,Amanda Kobs,Ashley C. Kramer,Mick Nyquist,Marcos T. Kuroki,John W. Osborn,Diane S. Lidke,Shalini T. Low-Nam,Bruce R. Blazar,Jakub Tolar +9 more
TL;DR: This is the first description of chemosensory detection by MSC and VSMCs via a taste receptor, and opens a new avenue of research into discovering novel compounds that operate through taste receptors expressed by cells in the marrow and vascular microenvironments.
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Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Cates Mallaney,Elizabeth L. Ostrander,Hamza Celik,Ashley C. Kramer,Andrew Martens,Alok Kothari,Won Kyun Koh,Emily Haussler,Naoki Iwamori,Paul Gontarz,Bo Zhang,Grant A. Challen +11 more
TL;DR: A crucial role is identified for Kdm6b in regulating HSC self-renewal in different contexts, and the potential of KDM6B as a therapeutic target in different hematopoietic malignancies is highlighted.
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JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
Hamza Celik,Won Kyun Koh,Ashley C. Kramer,Elizabeth L. Ostrander,Cates Mallaney,Daniel A.C. Fisher,Jingyu Xiang,William C. Wilson,Andrew Martens,Alok Kothari,Gregory Fishberger,Eric Tycksen,Darja Karpova,Eric J. Duncavage,Youngsook Lee,Stephen T. Oh,Grant A. Challen +16 more
TL;DR: In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders and identifies potential therapeutic targets.