D
D. van Soolingen
Researcher at Radboud University Nijmegen
Publications - 153
Citations - 14732
D. van Soolingen is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 55, co-authored 153 publications receiving 14086 citations. Previous affiliations of D. van Soolingen include Radboud University Nijmegen Medical Centre & Center for Infectious Disease Research and Policy.
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Journal ArticleDOI
Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology.
Judith Kamerbeek,Leo M. Schouls,Arend H. J. Kolk,M van Agterveld,D. van Soolingen,Sjoukje Kuijper,Annelies Bunschoten,H Molhuizen,R J Shaw,M Goyal,J. D. A. Van Embden +10 more
TL;DR: A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
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Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis.
TL;DR: The results indicate that M. tuberculosis strains from regions in central Africa, where tuberculosis is highly prevalent, are generally more related to each other than isolates from the Netherlands, where the transmission rate is low and where the majority of the tuberculosis cases are presumed to be the result of reactivation of previously contracted M.culosis infections.
Journal ArticleDOI
Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia.
D. van Soolingen,Lishi Qian,P. E. W. De Haas,James T. Douglas,Hamidou Traore,Françoise Portaels,H. Z. Qing,D. Enkhsaikan,Pagbajabyn Nymadawa,J. D. A. Van Embden +9 more
TL;DR: Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group, which is designated the "Beijing family" of M. tuberculosis strains, indicating that strains of the Beijing family recently expanded from a single ancestor which had a selective advantage.
Journal ArticleDOI
Comparison of Methods Based on Different Molecular Epidemiological Markers for Typing of Mycobacterium tuberculosis Complex Strains: Interlaboratory Study of Discriminatory Power and Reproducibility
Kristin Kremer,D. van Soolingen,Richard Frothingham,Walter H. Haas,Peter W. M. Hermans,Carlos Martin,Prasit Palittapongarnpim,Bonnie B. Plikaytis,Lee W. Riley,Mitchell A. Yakrus,James M. Musser,J. D. A. Van Embden +11 more
TL;DR: Strain differentiation by IS6110 RFLP or mixed-linker PCR are the methods of choice for epidemiological investigations, indicating a clonal population structure of M. tuberculosis strains.
Journal ArticleDOI
Comparison of various repetitive DNA elements as genetic markers for strain differentiation and epidemiology of Mycobacterium tuberculosis.
D. van Soolingen,P. E. W. De Haas,Peter W. M. Hermans,Peter M.A. Groenen,J. D. A. Van Embden +4 more
TL;DR: Five different genetic elements have been found to be associated with genetic rearrangements in Mycobacterium tuberculosis complex strains and the insertion sequence IS6110 is presently the most frequently used genetic marker for strain differentiation of M. tuberculosis.