D
Dong Han
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 8
Citations - 463
Dong Han is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Smoothened & Hedgehog signaling pathway. The author has an hindex of 6, co-authored 8 publications receiving 416 citations.
Papers
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Journal ArticleDOI
Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Shifeng Pan,Xu Wu,Jiqing Jiang,Wenqi Gao,Yongqin Wan,Dai Cheng,Dong Han,Jun Liu,Nathan P. Englund,Yan Wang,Stefan Peukert,Karen Miller-Moslin,Jing Yuan,Ribo Guo,Melissa Matsumoto,Anthony Vattay,Yun Jiang,Jeffrey Tsao,Fangxian Sun,AnneMarie Culazzo Pferdekamper,Stephanie Kay Dodd,Tove Tuntland,Wieslawa Maniara,Joseph Kelleher,Yung-mae Yao,Markus Warmuth,Juliet Williams,Marion Dorsch +27 more
TL;DR: Structural-activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl- 3-carboxamide (5m, NVP-LDE225), which is currently in clinical development.
Patent
Compounds and compositions as hedgehog pathway modulators
TL;DR: In this paper, a method for modulating the activity of the hedgehog signaling pathway was proposed, in which a cell with a sufficient amount of a compound of Formula I was contacted to prevent aberrant growth states.
Journal ArticleDOI
Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.
Dai Cheng,Jun Liu,Dong Han,Guobao Zhang,Wenqi Gao,Mindy H. Hsieh,Nicholas Ng,Shailaja Kasibhatla,Celin Tompkins,Jie Li,Auzon Steffy,Fangxian Sun,Chun Li,H. Martin Seidel,Jennifer L. Harris,Shifeng Pan +15 more
TL;DR: A cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation led to the discovery of a novel series of potent and selective Porcupine inhibitors.
Patent
Hedgehog pathway modulators
TL;DR: In this paper, a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway was proposed. In particular, the method provided a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of function, smoothened gain of function or GIi gain-ofthe-function.
Patent
Compounds and compositions as hedgehog signaling pathway modulators
TL;DR: In this article, a method for modulating the activity of the hedgehog signaling pathway was proposed, in which a cell with a sufficient amount of a compound of Formula I was contacted to prevent aberrant growth states.