J
Jun Liu
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 22
Citations - 4542
Jun Liu is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Wnt signaling pathway & LRP6. The author has an hindex of 16, co-authored 19 publications receiving 3857 citations. Previous affiliations of Jun Liu include Scripps Research Institute & Novartis.
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Journal ArticleDOI
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
William R. Wikoff,Andrew T. Anfora,Jun Liu,Peter G. Schultz,Scott A. Lesley,Eric C. Peters,Gary Siuzdak +6 more
TL;DR: A broad, drug-like phase II metabolic response of the host to metabolites generated by the microbiome was observed, suggesting that the gut microflora has a direct impact on the drug metabolism capacity of theHost.
Journal ArticleDOI
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu,Shifeng Pan,Mindy H. Hsieh,Nicholas Ng,Fangxian Sun,Tao Wang,Shailaja Kasibhatla,Alwin Schuller,Allen G. Li,Dai Cheng,Jie Li,Celin Tompkins,Anne Marie Pferdekamper,Auzon Steffy,Jane Cheng,Colleen Kowal,Van Phung,Gui-Rong Guo,Yan Wang,Martin P. Graham,Shannon Flynn,J. Chad Brenner,Chun Li,M. Cristina Villarroel,Peter G. Schultz,Xu Wu,Peter McNamara,William R. Sellers,Lilli Petruzzelli,Anthony Boral,H. Martin Seidel,Margaret E. McLaughlin,Jianwei Che,Thomas E. Carey,Gary J. Vanasse,Jennifer L. Harris +35 more
TL;DR: LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30).
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Shifeng Pan,Xu Wu,Jiqing Jiang,Wenqi Gao,Yongqin Wan,Dai Cheng,Dong Han,Jun Liu,Nathan P. Englund,Yan Wang,Stefan Peukert,Karen Miller-Moslin,Jing Yuan,Ribo Guo,Melissa Matsumoto,Anthony Vattay,Yun Jiang,Jeffrey Tsao,Fangxian Sun,AnneMarie Culazzo Pferdekamper,Stephanie Kay Dodd,Tove Tuntland,Wieslawa Maniara,Joseph Kelleher,Yung-mae Yao,Markus Warmuth,Juliet Williams,Marion Dorsch +27 more
TL;DR: Structural-activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl- 3-carboxamide (5m, NVP-LDE225), which is currently in clinical development.
Journal ArticleDOI
Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP
Eric Miller,Jiayi Yang,Michael DeRan,Chunlei Wu,Andrew I. Su,Ghislain M. C. Bonamy,Jun Liu,Eric C. Peters,Xu Wu +8 more
TL;DR: In this paper, small molecule activators of YAP were identified through chemical isolation and activity profiling, including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA).
Journal ArticleDOI
Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
Michael DeRan,Jiayi Yang,Che-Hung Shen,Eric C. Peters,Julien Fitamant,PuiYee Chan,Mindy H. Hsieh,Shunying Zhu,John M. Asara,Bin Zheng,Nabeel Bardeesy,Jun Liu,Xu Wu +12 more
TL;DR: This work shows that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation and suggests that YAP may integrate spatial, mechanical, and metabolic signals to control cellular proliferation and survival.