W
Wenqi Gao
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 19
Citations - 933
Wenqi Gao is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Smoothened & Receptor. The author has an hindex of 9, co-authored 19 publications receiving 847 citations. Previous affiliations of Wenqi Gao include Novartis.
Papers
More filters
Journal ArticleDOI
Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Shifeng Pan,Xu Wu,Jiqing Jiang,Wenqi Gao,Yongqin Wan,Dai Cheng,Dong Han,Jun Liu,Nathan P. Englund,Yan Wang,Stefan Peukert,Karen Miller-Moslin,Jing Yuan,Ribo Guo,Melissa Matsumoto,Anthony Vattay,Yun Jiang,Jeffrey Tsao,Fangxian Sun,AnneMarie Culazzo Pferdekamper,Stephanie Kay Dodd,Tove Tuntland,Wieslawa Maniara,Joseph Kelleher,Yung-mae Yao,Markus Warmuth,Juliet Williams,Marion Dorsch +27 more
TL;DR: Structural-activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl- 3-carboxamide (5m, NVP-LDE225), which is currently in clinical development.
Patent
Immunosuppressant compounds and compositions
TL;DR: In this paper, a class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction, are presented.
Journal ArticleDOI
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
Shifeng Pan,Nathanael S. Gray,Wenqi Gao,Yuan Mi,Yi Fan,Xing Wang,Tove Tuntland,Jianwei Che,Sophie Lefebvre,Yu Chen,Alan Chu,Klaus Hinterding,Anne Gardin,Peter End,Peter Heining,Christian Bruns,Nigel Graham Cooke,Barbara Nuesslein-Hildesheim +17 more
TL;DR: A novel series of alkoxyimino derivatives as S1P1 agonists were discovered through de novo design using FTY720 as the chemical starting point, which has recently completed phase 2 clinical trials in patients with relapsing-remitting multiple sclerosis.
Journal ArticleDOI
A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model
Shifeng Pan,Yuan Mi,Charles Pally,Christian Beerli,Alice Chen,Danilo Guerini,Klaus Hinterding,Barbara Nuesslein-Hildesheim,Tove Tuntland,Sophie Lefebvre,Yi Liu,Wenqi Gao,Alan Chu,Volker Brinkmann,Christian Bruns,Markus Streiff,Catherine Cannet,Nigel Graham Cooke,Nathanael S. Gray,Nathanael S. Gray +19 more
TL;DR: AUY954, an aminocarboxylate analog of FTY720, is a low nanomolar, monoselective agonist of the S1P(1) receptor and, in combination with RAD001, is capable of prolonging the survival of cardiac allografts in a stringent rat transplantation model.
Journal ArticleDOI
Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.
Dai Cheng,Jun Liu,Dong Han,Guobao Zhang,Wenqi Gao,Mindy H. Hsieh,Nicholas Ng,Shailaja Kasibhatla,Celin Tompkins,Jie Li,Auzon Steffy,Fangxian Sun,Chun Li,H. Martin Seidel,Jennifer L. Harris,Shifeng Pan +15 more
TL;DR: A cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation led to the discovery of a novel series of potent and selective Porcupine inhibitors.