Y
Yan Wang
Researcher at Peking Union Medical College
Publications - 81
Citations - 3736
Yan Wang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 26, co-authored 64 publications receiving 3090 citations. Previous affiliations of Yan Wang include Novartis & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu,Shifeng Pan,Mindy H. Hsieh,Nicholas Ng,Fangxian Sun,Tao Wang,Shailaja Kasibhatla,Alwin Schuller,Allen G. Li,Dai Cheng,Jie Li,Celin Tompkins,Anne Marie Pferdekamper,Auzon Steffy,Jane Cheng,Colleen Kowal,Van Phung,Gui-Rong Guo,Yan Wang,Martin P. Graham,Shannon Flynn,J. Chad Brenner,Chun Li,M. Cristina Villarroel,Peter G. Schultz,Xu Wu,Peter McNamara,William R. Sellers,Lilli Petruzzelli,Anthony Boral,H. Martin Seidel,Margaret E. McLaughlin,Jianwei Che,Thomas E. Carey,Gary J. Vanasse,Jennifer L. Harris +35 more
TL;DR: LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30).
Journal ArticleDOI
Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Shifeng Pan,Xu Wu,Jiqing Jiang,Wenqi Gao,Yongqin Wan,Dai Cheng,Dong Han,Jun Liu,Nathan P. Englund,Yan Wang,Stefan Peukert,Karen Miller-Moslin,Jing Yuan,Ribo Guo,Melissa Matsumoto,Anthony Vattay,Yun Jiang,Jeffrey Tsao,Fangxian Sun,AnneMarie Culazzo Pferdekamper,Stephanie Kay Dodd,Tove Tuntland,Wieslawa Maniara,Joseph Kelleher,Yung-mae Yao,Markus Warmuth,Juliet Williams,Marion Dorsch +27 more
TL;DR: Structural-activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl- 3-carboxamide (5m, NVP-LDE225), which is currently in clinical development.
Journal ArticleDOI
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
Jacob D. Jaffe,Yan Wang,Ho Man Chan,Jinghui Zhang,Robert Huether,Gregory V. Kryukov,Gregory V. Kryukov,Gregory V. Kryukov,Hyo-eun C. Bhang,Jordan E. Taylor,Min Hu,Nathan P. Englund,Feng Yan,Zhaofu Wang,E. Robert McDonald,Lei Wei,Jing Ma,John Easton,Zhengtian Yu,Rosalie deBeaumount,Veronica Gibaja,Kavitha Venkatesan,Robert Schlegel,William R. Sellers,Nicholas Keen,Jun Liu,Giordano Caponigro,Jordi Barretina,Vesselina G. Cooke,Charles G. Mullighan,Steven A. Carr,James R. Downing,Levi A. Garraway,Levi A. Garraway,Frank Stegmeier +34 more
TL;DR: In this article, a high-information-content mass spectrometry approach was developed to profile global histone modifications in human cancers. When applied to 115 lines from the Cancer Cell Line Encyclopedia1, this approach identified distinct molecular chromatin signatures.
Journal ArticleDOI
Transforming berberine into its intestine-absorbable form by the gut microbiota.
Ru Feng,Jia-Wen Shou,Zhen-Xiong Zhao,Chi-Yu He,Chao Ma,Min Huang,Jie Fu,Xiang-Shan Tan,Xiao-Yang Li,Bao-Ying Wen,Xi Chen,Xinyi Yang,Gang Ren,Yuan Lin,Yangchao Chen,Xuefu You,Yan Wang,Jian-Dong Jiang +17 more
TL;DR: It is shown that the gut microbiota converts BBR into its absorbable form of dihydroberberine (dhBBR), which has an intestinal absorption rate 5-fold that of BBR in animals.
Journal ArticleDOI
Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats
Xiang-Shan Tan,Jing-Yi Ma,Ru Feng,Chao Ma,Wen-Jing Chen,Yu-Peng Sun,Jie Fu,Min Huang,Chi-Yu He,Jia-Wen Shou,Wen-Yi He,Yan Wang,Jian-Dong Jiang +12 more
TL;DR: The organ concentration of BBR (as well as its bioactive metabolites) was higher than its concentration in the blood after oral administration, which might explain BBR’s pharmacological effects on human diseases in clinic.