E
Edward S. Boyden
Researcher at Massachusetts Institute of Technology
Publications - 556
Citations - 46974
Edward S. Boyden is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Optogenetics & Biological neural network. The author has an hindex of 92, co-authored 523 publications receiving 38803 citations. Previous affiliations of Edward S. Boyden include McGovern Institute for Brain Research & Howard Hughes Medical Institute.
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Journal ArticleDOI
Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Two channelrhodopsins, Chronos and Chrimson, are described, discovered through sequencing and physiological characterization of opsins from over 100 species of alga, that enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Linda Madisen,Tianyi Mao,Tianyi Mao,Henner Koch,Jia-Min Zhuo,Antal Berényi,Shigeyoshi Fujisawa,Yun Wei A Hsu,Alfredo J. Garcia,Xuan Gu,Sebastien Zanella,Jolene Kidney,Hong Gu,Yimei Mao,Bryan M. Hooks,Edward S. Boyden,György Buzsáki,Jan-Marino Ramirez,Allan R. Jones,Karel Svoboda,Xue Han,Eric E. Turner,Hongkui Zeng +22 more
TL;DR: The robust, consistent and inducible nature of the ChR2 mice represents a significant advance over previous lines, and the Arch-ER2 and eNpHR3.0 mice are to the authors' knowledge the first demonstration of successful conditional transgenic optogenetic silencing.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
High-performance genetically targetable optical neural silencing by light-driven proton pumps
Brian Y. Chow,Xue Han,Xue Han,Allison S. Dobry,Allison S. Dobry,Xiaofeng Qian,Xiaofeng Qian,Amy S. Chuong,Amy S. Chuong,Mingjie Li,Mingjie Li,Henninger Michael,Henninger Michael,Gabriel M. Belfort,Yingxi Lin,Patrick E. Monahan,Patrick E. Monahan,Edward S. Boyden,Edward S. Boyden +18 more
TL;DR: Light-driven proton pumps represent a high-performance and extremely versatile class of ‘optogenetic’ voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations.