H
Hongkui Zeng
Researcher at Allen Institute for Brain Science
Publications - 271
Citations - 33933
Hongkui Zeng is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Biology & Cell type. The author has an hindex of 67, co-authored 235 publications receiving 23795 citations. Previous affiliations of Hongkui Zeng include Massachusetts Institute of Technology & Allen Institute for Artificial Intelligence.
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Journal ArticleDOI
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
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A mesoscale connectome of the mouse brain
Seung Wook Oh,Julie A. Harris,Lydia Ng,Brent Winslow,Nicholas Cain,Stefan Mihalas,Quanxin Wang,Chris Lau,Leonard Kuan,Alex M. Henry,Marty Mortrud,Benjamin Ouellette,Thuc Nghi Nguyen,Staci A. Sorensen,Clifford R. Slaughterbeck,Wayne Wakeman,Yang Li,David Feng,Anh Ho,Eric Nicholas,Karla E. Hirokawa,Phillip Bohn,Kevin M. Joines,Hanchuan Peng,Michael Hawrylycz,John W. Phillips,John G. Hohmann,Paul Wohnoutka,Charles R. Gerfen,Christof Koch,Amy Bernard,Chinh Dang,Allan R. Jones,Hongkui Zeng +33 more
TL;DR: A brain-wide, cellular-level, mesoscale connectome for the mouse, using enhanced green fluorescent protein-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain.
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Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Bosiljka Tasic,Vilas Menon,Thuc Nghi Nguyen,Tae Kyung Kim,Tim Jarsky,Zizhen Yao,Boaz P. Levi,Lucas T. Gray,Staci A. Sorensen,Tim A. Dolbeare,Darren Bertagnolli,Jeff Goldy,Nadiya V. Shapovalova,Sheana Parry,Changkyu Lee,Kimberly A. Smith,Amy Bernard,Linda Madisen,Susan M. Sunkin,Michael Hawrylycz,Christof Koch,Hongkui Zeng +21 more
TL;DR: This work constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing and identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types.
Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Journal ArticleDOI
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Linda Madisen,Tianyi Mao,Tianyi Mao,Henner Koch,Jia-Min Zhuo,Antal Berényi,Shigeyoshi Fujisawa,Yun Wei A Hsu,Alfredo J. Garcia,Xuan Gu,Sebastien Zanella,Jolene Kidney,Hong Gu,Yimei Mao,Bryan M. Hooks,Edward S. Boyden,György Buzsáki,Jan-Marino Ramirez,Allan R. Jones,Karel Svoboda,Xue Han,Eric E. Turner,Hongkui Zeng +22 more
TL;DR: The robust, consistent and inducible nature of the ChR2 mice represents a significant advance over previous lines, and the Arch-ER2 and eNpHR3.0 mice are to the authors' knowledge the first demonstration of successful conditional transgenic optogenetic silencing.