H
Hong Gu
Researcher at Allen Institute for Brain Science
Publications - 18
Citations - 9204
Hong Gu is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Visual cortex & Glutamatergic. The author has an hindex of 12, co-authored 16 publications receiving 7038 citations.
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Journal ArticleDOI
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
Journal ArticleDOI
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Linda Madisen,Tianyi Mao,Tianyi Mao,Henner Koch,Jia-Min Zhuo,Antal Berényi,Shigeyoshi Fujisawa,Yun Wei A Hsu,Alfredo J. Garcia,Xuan Gu,Sebastien Zanella,Jolene Kidney,Hong Gu,Yimei Mao,Bryan M. Hooks,Edward S. Boyden,György Buzsáki,Jan-Marino Ramirez,Allan R. Jones,Karel Svoboda,Xue Han,Eric E. Turner,Hongkui Zeng +22 more
TL;DR: The robust, consistent and inducible nature of the ChR2 mice represents a significant advance over previous lines, and the Arch-ER2 and eNpHR3.0 mice are to the authors' knowledge the first demonstration of successful conditional transgenic optogenetic silencing.
Journal ArticleDOI
Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.
Linda Madisen,Aleena R. Garner,Daisuke Shimaoka,Amy S. Chuong,Nathan C. Klapoetke,Lu Li,Alexander van der Bourg,Yusuke Niino,Ladan Egolf,Claudio Monetti,Hong Gu,Maya Mills,Adrian Cheng,Bosiljka Tasic,Thuc Nghi Nguyen,Susan M. Sunkin,Andrea Benucci,Andras Nagy,Atsushi Miyawaki,Fritjof Helmchen,Ruth M. Empson,Thomas Knöpfel,Edward S. Boyden,R. Clay Reid,Matteo Carandini,Hongkui Zeng +25 more
TL;DR: These novel transgenic lines greatly expand the ability to monitor and manipulate neuronal activities with increased specificity, and develop driver and double reporter mouse lines and viral vectors using the Cre/Flp and Cre/Dre double recombinase systems.
Journal ArticleDOI
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Tanya L. Daigle,Linda Madisen,Travis A. Hage,Matthew T. Valley,Ulf Knoblich,Rylan S. Larsen,Marc Takeno,Lawrence Huang,Hong Gu,Rachael Larsen,Maya Mills,Alice Bosma-Moody,La'Akea Siverts,Miranda Walker,Lucas T. Graybuck,Zizhen Yao,Olivia Fong,Thuc Nghi Nguyen,Emma Garren,Garreck H. Lenz,Mariya Chavarha,Julie Pendergraft,James Harrington,Karla E. Hirokawa,Julie A. Harris,Philip R. Nicovich,Medea McGraw,Douglas R. Ollerenshaw,Kimberly A. Smith,Christopher A. Baker,Jonathan T. Ting,Susan M. Sunkin,Jérôme Lecoq,Michael Z. Lin,Edward S. Boyden,Gabe J. Murphy,Nuno Maçarico da Costa,Jack Waters,Lu Li,Bosiljka Tasic,Hongkui Zeng +40 more
TL;DR: A large set of driver and reporter transgenic mouse lines are reported, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools.
Journal ArticleDOI
Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation
Julie A. Harris,Karla E. Hirokawa,Staci A. Sorensen,Hong Gu,Maya Mills,Lydia Ng,Phillip Bohn,Marty Mortrud,Benjamin Ouellette,Jolene Kidney,Kimberly A. Smith,Chinh Dang,Susan M. Sunkin,Amy Bernard,Seung Wook Oh,Linda Madisen,Hongkui Zeng +16 more
TL;DR: A high-throughput in situ hybridization (ISH), imaging and data processing pipeline to describe whole brain gene expression patterns in Cre driver mice is established and publicly available via the Allen Institute's Transgenic Characterization database.