G
Gerhard Eisenbrand
Researcher at Kaiserslautern University of Technology
Publications - 327
Citations - 11631
Gerhard Eisenbrand is an academic researcher from Kaiserslautern University of Technology. The author has contributed to research in topics: DNA damage & Indirubin. The author has an hindex of 46, co-authored 317 publications receiving 10446 citations. Previous affiliations of Gerhard Eisenbrand include Schering AG & Centre national de la recherche scientifique.
Papers
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Journal ArticleDOI
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Ralph Hoessel,Sophie Leclerc,Jane A. Endicott,Martin E. M. Nobel,Alison M. Lawrie,Paul Tunnah,Maryse Leost,Eve Damiens,Dominique Marie,Doris Marko,Ellen Niederberger,Weici Tang,Gerhard Eisenbrand,Laurent Meijer +13 more
TL;DR: Indirubin-3′-monoxime inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle, which has implications for therapeutic optimization of indigoids.
Journal ArticleDOI
Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?
Sophie Leclerc,Matthieu Garnier,Ralph Hoessel,Doris Marko,James A. Bibb,Gretchen L. Snyder,Paul Greengard,Jacek Biernat,Yong-Zhong Wu,Eva-Maria Mandelkow,Gerhard Eisenbrand,Laurent Meijer +11 more
TL;DR: It is reported here that indirubins are also powerful inhibitors (IC(50): 5-50 nm) of an evolutionarily related kinase, glycogen synthase kinase-3beta (GSK-3 beta), and it is shown that many, but not all, reported CDK inhibitors are powerful inhibitors of GSK-3 Beta.
Book
Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine
Weici Tang,Gerhard Eisenbrand +1 more
Journal ArticleDOI
Impact of food processing and detoxification treatments on mycotoxin contamination.
Petr Karlovsky,Michele Suman,Franz Berthiller,Johan De Meester,Gerhard Eisenbrand,Irène Perrin,Isabelle P. Oswald,Isabelle P. Oswald,G. J. A. Speijers,Alessandro Chiodini,Tobias Recker,Pierre Dussort +11 more
TL;DR: While physical techniques currently offer the most efficient post-harvest reduction of mycotoxin content in food, biotechnology possesses the largest potential for future developments.