H
Hatim A. Zariwala
Researcher at Allen Institute for Brain Science
Publications - 7
Citations - 6558
Hatim A. Zariwala is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Astrogliosis & Amyotrophic lateral sclerosis. The author has an hindex of 4, co-authored 4 publications receiving 5374 citations. Previous affiliations of Hatim A. Zariwala include Seattle Children's Research Institute & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
Journal ArticleDOI
Neural correlates, computation and behavioural impact of decision confidence
Adam Kepecs,Naoshige Uchida,Naoshige Uchida,Hatim A. Zariwala,Hatim A. Zariwala,Zachary F. Mainen,Zachary F. Mainen +6 more
TL;DR: The firing rates of many single neurons in the orbitofrontal cortex match closely to the predictions of confidence models and cannot be readily explained by alternative mechanisms, such as learning stimulus–outcome associations.
Journal ArticleDOI
A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo
Hatim A. Zariwala,Hatim A. Zariwala,Hatim A. Zariwala,Bart G. Borghuis,Bart G. Borghuis,Tycho M. Hoogland,Linda Madisen,Lin Tian,Chris I. De Zeeuw,Chris I. De Zeeuw,Hongkui Zeng,Loren L. Looger,Karel Svoboda,Tsai Wen Chen +13 more
TL;DR: The results show that the Ai38 reporter mouse provides a flexible method for targeted expression of GCaMP3, and allows imaging spontaneous calcium waves in starburst amacrine cells during development, and light-evoked responses in ganglion cells in adult tissue.
Journal ArticleDOI
Visual Tuning Properties of Genetically Identified Layer 2/3 Neuronal Types in the Primary Visual Cortex of Cre-Transgenic Mice
Hatim A. Zariwala,Hatim A. Zariwala,Linda Madisen,Kurt F. Ahrens,Amy Bernard,Edward S. Lein,Allan R. Jones,Hongkui Zeng +7 more
TL;DR: The utility of Cre-transgenic mouse technology in selective targeting of subpopulations of neurons and makes them amenable to structural, functional, and connectivity studies are demonstrated.
Journal ArticleDOI
SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function
Mukesh Gautam,Barış Genç,Ben Helmold,Angela Ahrens,Janis Kuka,Marina Makrecka-Kuka,Aksu Günay,Nuran Kocak,Izaak R. Aguilar-Wickings,Dennis Keefe,Guozhu Zheng,Suchitra Swaminathan,Martin Redmon,Hatim A. Zariwala,P. Hande Özdinler +14 more
TL;DR: SBT-272 as mentioned in this paper is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in IMM, thereby restoring mitochondrial structure and respiratory function.