P. Hande Özdinler

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is reported that insulin-like growth factor-1 (IGF-I) specifically enhances the extent and rate of murine CSMN axon outgrowth, mediated via the IGF-I receptor and downstream signaling pathways; this is distinct from IGF- I support of neuronal survival.

TL;DR: In vivo and in vitro studies find that PrP(c) is expressed in multipotent neural precursors and mature neurons but is not detectable in glia, and loss- and gain-of-function experiments demonstrate thatPrP( c) levels correlate with differentiation of multipotent Neural precursor into mature neurons in vitro and that PrPs positively influence neuronal differentiation in a dose-dependent manner.

TL;DR: Previously unknown neuron type-specific vulnerability of CSMN/sensory and association SCPN is indicated, and it is identified that characteristic dual CSMN and SMN degeneration is conserved in hSOD1G93A mice.

TL;DR: Changes in cortical function that develop in ALS could prove useful as diagnostic biomarkers, potentially enhancing the diagnosis of ALS at an early stage of the disease process and providing potential for more-effective management of patients with ALS.